Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide

Haerim Nam, Ji Eon Kwon, Min Woo Choi, Jangwon Seo, Seunghoon Shin, Sehoon Kim, Soo Young Park

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A novel nitronyl-nitroxide derivative for highly sensitive and selective detection of ascorbic acid (AA) is reported. The probe showed 260-fold fluorescence turn-on and diminished electron spin resonance (ESR) signal upon AA addition. The probe could detect AA over a broad concentration range from 1 μM to 2 mM and excellent selectivity over various antioxidants and acids through a combination of fluorescence and ESR responses, which originated from the dual-reactiveness of dual-quenching group nitronyl-nitroxide. We successfully demonstrated practical application potential of the probe by preparing nanoparticles and sensor papers and determining AA concentration in real samples including vitamin drinks and orange juices.

Original languageEnglish
Pages (from-to)392-398
Number of pages7
JournalACS Sensors
Volume1
Issue number4
DOIs
Publication statusPublished - 2016 Apr 22
Externally publishedYes

Fingerprint

ascorbic acid
Ascorbic acid
Fluorescent Dyes
Ascorbic Acid
Quenching
quenching
probes
Paramagnetic resonance
electron paramagnetic resonance
Fluorescence
juices
vitamins
fluorescence
Vitamins
antioxidants
Antioxidants
selectivity
Nanoparticles
Derivatives
nanoparticles

Keywords

  • ascorbic acid
  • electron spin resonance
  • fluorescence
  • nitronyl-nitroxide
  • sensor

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes

Cite this

Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide. / Nam, Haerim; Kwon, Ji Eon; Choi, Min Woo; Seo, Jangwon; Shin, Seunghoon; Kim, Sehoon; Park, Soo Young.

In: ACS Sensors, Vol. 1, No. 4, 22.04.2016, p. 392-398.

Research output: Contribution to journalArticle

Nam, Haerim ; Kwon, Ji Eon ; Choi, Min Woo ; Seo, Jangwon ; Shin, Seunghoon ; Kim, Sehoon ; Park, Soo Young. / Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide. In: ACS Sensors. 2016 ; Vol. 1, No. 4. pp. 392-398.
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