Highly stable, amphiphilic DNA-encoded nanoparticle conjugates for DNA encoding/decoding applications

Dong-Kwon Lim, Min Hao Cui, Jwa Min Nam

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We synthesized highly stable, amphiphilic polymer-protected DNA-Au nanoparticle conjugates (DNA-AuNPs) and developed a DNA encoding/decoding strategy using these particles. Here, DNA-AuNPs were encapsulated by amphiphilic poly(N-vinyl-2-pyrrolidone) (PVP) to make them more stable and soluble in both organic and aqueous solvents. These particles are stable in a wide range of salt concentrations, pH and temperatures and sustain their stability even after the addition of d,l-dithiothreitol. Finally, this polymer layer was readily removed and particle-modified DNA was decoded via the microarrayed chip and dark-field-based AuNP imaging technique.

Original languageEnglish
Pages (from-to)9467-9470
Number of pages4
JournalJournal of Materials Chemistry
Volume21
Issue number26
DOIs
Publication statusPublished - 2011 Jul 14
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

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