Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

Yoonhee Bae, Dongwon Choi, Hyangshuk Rhim, Seong Man Kang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT- 8045218, MINT- 8045231: Hip2 (uniprotkb: P61086) physically interacts (MI: 0915) with cyclin-B1 (uniprotkb: P14635) by pull down (MI: 0096).

Original languageEnglish
Pages (from-to)4505-4510
Number of pages6
JournalFEBS Letters
Volume584
Issue number22
DOIs
Publication statusPublished - 2010 Nov 19

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Keywords

  • Apoptosis
  • Cyclin B1
  • Hip2
  • Ubiquitination

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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