Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: Comparison with amyloid-positive mild cognitive impairment

Byoung Seok Ye, Sang Won Seo, Chi Hun Kim, Seun Jeon, Geon Ha Kim, Young Noh, Hanna Cho, Cindy W. Yoon, Hee Jin Kim, Eun Young Jang, Jeongmin Lee, Jung Hyun Kim, Juhee Chin, Jong Min Lee, Jeong Hun Kim, Jun Kyung Seong, Chang-Hun Kim, Yearn Seong Choe, Kyung Han Lee, Duk L. Na

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19 Citations (Scopus)

Abstract

Although patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer's disease (AD), their pathologies could be heterogeneous. We aimed to evaluate structural changes in amyloid-negative and amyloid-positive aMCI patients. Forty-eight aMCI patients who underwent Pittsburgh compound B (PiB) positron emission tomography were recruited. They were classified as PiB (-) aMCI (N= 16) and PiB (+) (N= 32). Hippocampal shape and regional cortical thickness were compared with 41 subjects with normal cognition (NC). Relative to NC, PiB(-) aMCI exhibited hippocampal deformity in the right cornu ammonis 1, whereas PiB(+) aMCI exhibited hippocampal deformity in bilateral subiculum and cornu ammonis 1 subregions. Relative to NC, PiB(-) aMCI showed cortical thinning in the left medial prefrontal and right anterior temporal regions, whereas PiB(+) aMCI exhibited cortical thinning in bilateral medial temporal regions, temporoparietal junctions and precuneus, and prefrontal cortices. Our findings suggest that structural changes in PiB(-) aMCI might be due to several possible pathologic changes, whereas structural changes in PiB(+) aMCI reflect AD-like structural changes.

Original languageEnglish
Pages (from-to)291-300
Number of pages10
JournalNeurobiology of Aging
Volume35
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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Keywords

  • Alzheimer's disease
  • Cortical thickness
  • Hippocampus
  • Mild cognitive impairment
  • Pittsburgh compound B

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Ye, B. S., Seo, S. W., Kim, C. H., Jeon, S., Kim, G. H., Noh, Y., Cho, H., Yoon, C. W., Kim, H. J., Jang, E. Y., Lee, J., Kim, J. H., Chin, J., Lee, J. M., Kim, J. H., Seong, J. K., Kim, C-H., Choe, Y. S., Lee, K. H., & Na, D. L. (2014). Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: Comparison with amyloid-positive mild cognitive impairment. Neurobiology of Aging, 35(2), 291-300. https://doi.org/10.1016/j.neurobiolaging.2013.08.017