Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim, Jae Hong Lee, Sang Won Seo, Jeong Hun Kim, Jun Kyung Seong, Byoung Seok Ye, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Jung Won Hwang, Jee Hyang Jeong, Duk L. Na

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalNeurobiology of Aging
Volume36
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

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Vascular Dementia
Alzheimer Disease
Cognition
Hippocampus
Cornus
Atrophy
Amyloid
Positron-Emission Tomography
Ischemia
Pathology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Hippocampal volume and shape in pure subcortical vascular dementia. / Kim, Geon Ha; Lee, Jae Hong; Seo, Sang Won; Kim, Jeong Hun; Seong, Jun Kyung; Ye, Byoung Seok; Cho, Hanna; Noh, Young; Kim, Hee Jin; Yoon, Cindy W.; Oh, Seung Jun; Kim, Jae Seung; Choe, Yearn Seong; Lee, Kyung Han; Kim, Sung Tae; Hwang, Jung Won; Jeong, Jee Hyang; Na, Duk L.

In: Neurobiology of Aging, Vol. 36, No. 1, 01.01.2015, p. 485-491.

Research output: Contribution to journalArticle

Kim, GH, Lee, JH, Seo, SW, Kim, JH, Seong, JK, Ye, BS, Cho, H, Noh, Y, Kim, HJ, Yoon, CW, Oh, SJ, Kim, JS, Choe, YS, Lee, KH, Kim, ST, Hwang, JW, Jeong, JH & Na, DL 2015, 'Hippocampal volume and shape in pure subcortical vascular dementia', Neurobiology of Aging, vol. 36, no. 1, pp. 485-491. https://doi.org/10.1016/j.neurobiolaging.2014.08.009
Kim, Geon Ha ; Lee, Jae Hong ; Seo, Sang Won ; Kim, Jeong Hun ; Seong, Jun Kyung ; Ye, Byoung Seok ; Cho, Hanna ; Noh, Young ; Kim, Hee Jin ; Yoon, Cindy W. ; Oh, Seung Jun ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Kim, Sung Tae ; Hwang, Jung Won ; Jeong, Jee Hyang ; Na, Duk L. / Hippocampal volume and shape in pure subcortical vascular dementia. In: Neurobiology of Aging. 2015 ; Vol. 36, No. 1. pp. 485-491.
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