Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim; Jae Hong Lee; Sang Won Seo; Jeong Hun Kim; Joon Kyung Seong; Byoung Seok Ye; Hanna Cho; Young Noh; Hee Jin Kim; Cindy W. Yoon; Seung Jun Oh; Jae Seung Kim; Yearn Seong Choe; Kyung Han Lee; Sung Tae Kim; Jung Won Hwang; Jee Hyang Jeong; Duk L. Na

doi:10.1016/j.neurobiolaging.2014.08.009

Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim, Jae Hong Lee, Sang Won Seo, Jeong Hun Kim, Joon Kyung Seong, Byoung Seok Ye, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Jung Won Hwang, Jee Hyang Jeong, Duk L. Na

School of Biomedical Engineering

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative ¹¹C-Pittsburg compound-B (PiB^-) positron emission tomography and to compare hippocampal volume and shape between PiB^- SVaD and PiB positive (PiB⁺) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB^- SVaD, 34 with PiB⁺ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB^- SVaD was significantly smaller than NC but larger than that of PiB⁺ AD (NC > PiB^- SVaD > PiB⁺ AD). Both PiB^- SVaD and PiB⁺ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB^- SVaD and PiB⁺ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB⁺ AD. PiB^- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

Original language	English
Pages (from-to)	485-491
Number of pages	7
Journal	Neurobiology of Aging
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.08.009
Publication status	Published - 2015 Jan 1

Keywords

Alzheimer's disease
Hippocampus
PiB-PET
Vascular dementia

ASJC Scopus subject areas

Neuroscience(all)
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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Kim, G. H., Lee, J. H., Seo, S. W., Kim, J. H., Seong, J. K., Ye, B. S., Cho, H., Noh, Y., Kim, H. J., Yoon, C. W., Oh, S. J., Kim, J. S., Choe, Y. S., Lee, K. H., Kim, S. T., Hwang, J. W., Jeong, J. H., & Na, D. L. (2015). Hippocampal volume and shape in pure subcortical vascular dementia. Neurobiology of Aging, 36(1), 485-491. https://doi.org/10.1016/j.neurobiolaging.2014.08.009

Hippocampal volume and shape in pure subcortical vascular dementia. / Kim, Geon Ha; Lee, Jae Hong; Seo, Sang Won; Kim, Jeong Hun; Seong, Joon Kyung; Ye, Byoung Seok; Cho, Hanna; Noh, Young; Kim, Hee Jin; Yoon, Cindy W.; Oh, Seung Jun; Kim, Jae Seung; Choe, Yearn Seong; Lee, Kyung Han; Kim, Sung Tae; Hwang, Jung Won; Jeong, Jee Hyang; Na, Duk L.

In: Neurobiology of Aging, Vol. 36, No. 1, 01.01.2015, p. 485-491.

Research output: Contribution to journal › Article

Kim, Geon Ha ; Lee, Jae Hong ; Seo, Sang Won ; Kim, Jeong Hun ; Seong, Joon Kyung ; Ye, Byoung Seok ; Cho, Hanna ; Noh, Young ; Kim, Hee Jin ; Yoon, Cindy W. ; Oh, Seung Jun ; Kim, Jae Seung ; Choe, Yearn Seong ; Lee, Kyung Han ; Kim, Sung Tae ; Hwang, Jung Won ; Jeong, Jee Hyang ; Na, Duk L. / Hippocampal volume and shape in pure subcortical vascular dementia. In: Neurobiology of Aging. 2015 ; Vol. 36, No. 1. pp. 485-491.

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abstract = "The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.",

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AU - Choe, Yearn Seong

AU - Lee, Kyung Han

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AB - The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

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