@article{1e733025a07b45c9af07dade99eb5139,
title = "Hippocampal volume and shape in pure subcortical vascular dementia",
abstract = "The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.",
keywords = "Alzheimer's disease, Hippocampus, PiB-PET, Vascular dementia",
author = "Kim, {Geon Ha} and Lee, {Jae Hong} and Seo, {Sang Won} and Kim, {Jeong Hun} and Seong, {Joon Kyung} and Ye, {Byoung Seok} and Hanna Cho and Young Noh and Kim, {Hee Jin} and Yoon, {Cindy W.} and Oh, {Seung Jun} and Kim, {Jae Seung} and Choe, {Yearn Seong} and Lee, {Kyung Han} and Kim, {Sung Tae} and Hwang, {Jung Won} and Jeong, {Jee Hyang} and Na, {Duk L.}",
note = "Funding Information: This study was supported by a grant from the Korean Healthcare Technology R&D Project, the Ministry for Health , Welfare and Family Affairs , the Republic of Korea ( HI10C2020 ), the Korean Science and Engineering Foundation NRL program grant funded by the Korean Government ( MEST, 2011–0028333 ), the Samsung Medical Center Clinical Research Development Program grant (CRL-108011 and CRS 110-14-1), and the Converging Research Center Program through the Ministry of Science, ICT and Future Planning, Korea (2013K000338). Author contributions—conception and design, data analysis and interpretation, and manuscript writing: GH Kim, MD, and Lee, MD; collection and assembly of data: Cho, MD, Noh, MD, HJ Kim, MD, Yoon, MD, Ye, MD, Oh, MD, JS Kim, MD, Choe, MD, Lee, MD, ST Kim Jeong, MD, and Hwang, BS, MD; data analysis and interpretation: JH Kim, PhD, and Seong, PhD; conception and design, administrative support, and data analysis and interpretation: Seo, MD; and conception and design, administrative support, data analysis and interpretation, manuscript writing, and final approval of manuscript: Na, MD. Funding Information: Drs GHK, HC, YN, CWY, HJK, SJO, JSK, YSC, KHL, STK, JHJ, and JHL and JHK, J-KS, and JWH report no disclosures. Dr SWS and Dr DLN receive research support from the Ministry of Health and Welfare, Korea. ",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.neurobiolaging.2014.08.009",
language = "English",
volume = "36",
pages = "485--491",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "1",
}