Histologic type, staging, and distribution of germ cell tumors in Korean adults

Dong Soo Park, Moon Kee Chung, Jae Il Chung, Han Jong Ahn, Eun Sik Lee, Han Yong Choi, Duck Ki Yoon, Jun Cheon, Sung Joon Hong, Young Goo Lee, Sang Min Yoon, Wun Jae Kim, Hyung Jin Kim, Soo Bang Ryu, Jae Y. Ro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia. Methods: Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis. Results: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT. Conclusions: Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.

Original languageEnglish
Pages (from-to)590-594
Number of pages5
JournalUrologic Oncology: Seminars and Original Investigations
Volume26
Issue number6
DOIs
Publication statusPublished - 2008 Nov 1
Externally publishedYes

Fingerprint

Germ Cell and Embryonal Neoplasms
Seminoma
Testis
Neoplasms
Far East
Testicular Neoplasms
Mediastinum
Histology
Epidemiology
Central Nervous System
Neoplasm Metastasis
Incidence

Keywords

  • Epidemiology
  • Germ cell
  • Histology
  • Stage
  • Tumor

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Park, D. S., Chung, M. K., Chung, J. I., Ahn, H. J., Lee, E. S., Choi, H. Y., ... Ro, J. Y. (2008). Histologic type, staging, and distribution of germ cell tumors in Korean adults. Urologic Oncology: Seminars and Original Investigations, 26(6), 590-594. https://doi.org/10.1016/j.urolonc.2007.07.012

Histologic type, staging, and distribution of germ cell tumors in Korean adults. / Park, Dong Soo; Chung, Moon Kee; Chung, Jae Il; Ahn, Han Jong; Lee, Eun Sik; Choi, Han Yong; Yoon, Duck Ki; Cheon, Jun; Hong, Sung Joon; Lee, Young Goo; Yoon, Sang Min; Kim, Wun Jae; Kim, Hyung Jin; Ryu, Soo Bang; Ro, Jae Y.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 26, No. 6, 01.11.2008, p. 590-594.

Research output: Contribution to journalArticle

Park, DS, Chung, MK, Chung, JI, Ahn, HJ, Lee, ES, Choi, HY, Yoon, DK, Cheon, J, Hong, SJ, Lee, YG, Yoon, SM, Kim, WJ, Kim, HJ, Ryu, SB & Ro, JY 2008, 'Histologic type, staging, and distribution of germ cell tumors in Korean adults', Urologic Oncology: Seminars and Original Investigations, vol. 26, no. 6, pp. 590-594. https://doi.org/10.1016/j.urolonc.2007.07.012
Park, Dong Soo ; Chung, Moon Kee ; Chung, Jae Il ; Ahn, Han Jong ; Lee, Eun Sik ; Choi, Han Yong ; Yoon, Duck Ki ; Cheon, Jun ; Hong, Sung Joon ; Lee, Young Goo ; Yoon, Sang Min ; Kim, Wun Jae ; Kim, Hyung Jin ; Ryu, Soo Bang ; Ro, Jae Y. / Histologic type, staging, and distribution of germ cell tumors in Korean adults. In: Urologic Oncology: Seminars and Original Investigations. 2008 ; Vol. 26, No. 6. pp. 590-594.
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abstract = "Objectives: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia. Methods: Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis. Results: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67{\%}); central nervous system (CNS) 137 cases (20{\%}); mediastinum 78 cases (11{\%}), and retroperitoneum 12 cases (2{\%}); 239 (51{\%}) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58{\%}), 73 (33{\%}), and 21 (9{\%}) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99{\%}) patients were classified with a good prognosis and 3 (1{\%}) with an intermediate prognosis amongst seminomas of testis; 193 (82{\%}) cases presented as stage I testicular seminoma whereas 120 (54{\%}) cases presented as stage I NSGCT. Conclusions: Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.",
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T1 - Histologic type, staging, and distribution of germ cell tumors in Korean adults

AU - Park, Dong Soo

AU - Chung, Moon Kee

AU - Chung, Jae Il

AU - Ahn, Han Jong

AU - Lee, Eun Sik

AU - Choi, Han Yong

AU - Yoon, Duck Ki

AU - Cheon, Jun

AU - Hong, Sung Joon

AU - Lee, Young Goo

AU - Yoon, Sang Min

AU - Kim, Wun Jae

AU - Kim, Hyung Jin

AU - Ryu, Soo Bang

AU - Ro, Jae Y.

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N2 - Objectives: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia. Methods: Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis. Results: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT. Conclusions: Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.

AB - Objectives: To investigate the presentation of germ cell tumors (GCT) in terms of histology and stage, to better clarify the epidemiology of this disease in eastern Asia. Methods: Six hundred ninety-eight patients diagnosed with GCT between 1995 and 2004 were analyzed. Clinical parameters at the time of initial diagnosis were classified in terms of the American Joint Committee on Cancer (AJCC) tumor, nodes, metastasis staging (TNMS) system, the International Germ Cell Cancer Collaborative Classification (IGCCC), for high-risk stage I nonseminomatous GCT (NSGCT) of testis. Results: The anatomic distributions for the primary sites of the observed tumors were as follows: testis 471 cases (67%); central nervous system (CNS) 137 cases (20%); mediastinum 78 cases (11%), and retroperitoneum 12 cases (2%); 239 (51%) of 471 tumors with testicular primary were seminoma. High risk vs. non-high risk stage I NSGCT cases were 62 vs. 58. Of NSGCT of testis, 129 (58%), 73 (33%), and 21 (9%) of tumors presented with good, intermediate, and poor prognosis, respectively, based on IGCCC, whereas 231 (99%) patients were classified with a good prognosis and 3 (1%) with an intermediate prognosis amongst seminomas of testis; 193 (82%) cases presented as stage I testicular seminoma whereas 120 (54%) cases presented as stage I NSGCT. Conclusions: Extragonadal primary GCTs are very common in Korean. Incidence of high risk NSGCT of testis with stage I disease was lower than in the Western report. NSGCT presents itself as a more aggressive form whereas seminoma is a very indolent tumor when compared with cases in Western countries.

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