History of pneumonia is a strong risk factor for chronic obstructive pulmonary disease (COPD) exacerbation in South Korea

The Epidemiologic review and Prospective Observation of COPD and Health in Korea (EPOCH) study

Yong Il Hwang, Sang Haak Lee, Jee Hong Yoo, Bock Hyun Jung, Kwang Ha Yoo, Moon Jun Na, Jong Deog Lee, Myung Jae Park, Chi Young Jung, Jae Jeong Shim, Kyung Chan Kim, Yeon Jae Kim, Hye Sook Choi, Ik Su Choi, Choon Taek Lee, Sang Do Lee, Do Jin Kim, Soo Taek Uh, Ho Sung Lee, Young Sam Kim & 9 others Kwan Ho Lee, Seung Won Ra, Hak Ryul Kim, Soo Jeon Choi, In Won Park, Yong Bum Park, So Young Park, Jaehee Lee, Ki Suck Jung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPD patients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPD patients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. Methods: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. Results: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8%) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. Conclusions: This study examined the demographic and clinical characteristics of South Korean COPD patients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.

Original languageEnglish
Pages (from-to)2203-2213
Number of pages11
JournalJournal of Thoracic Disease
Volume7
Issue number12
DOIs
Publication statusPublished - 2015 Jan 1

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Republic of Korea
Korea
Chronic Obstructive Pulmonary Disease
Disease Progression
Pneumonia
Observation
Health
Cause of Death
Epidemiology
Logistic Models
Demography

Keywords

  • Chronic bronchitis
  • Chronic obstructive pulmonary disease (COPD)
  • Exacerbation
  • Pneumonia
  • South Korea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

History of pneumonia is a strong risk factor for chronic obstructive pulmonary disease (COPD) exacerbation in South Korea : The Epidemiologic review and Prospective Observation of COPD and Health in Korea (EPOCH) study. / Hwang, Yong Il; Lee, Sang Haak; Yoo, Jee Hong; Jung, Bock Hyun; Yoo, Kwang Ha; Na, Moon Jun; Lee, Jong Deog; Park, Myung Jae; Jung, Chi Young; Shim, Jae Jeong; Kim, Kyung Chan; Kim, Yeon Jae; Choi, Hye Sook; Choi, Ik Su; Lee, Choon Taek; Lee, Sang Do; Kim, Do Jin; Uh, Soo Taek; Lee, Ho Sung; Kim, Young Sam; Lee, Kwan Ho; Ra, Seung Won; Kim, Hak Ryul; Choi, Soo Jeon; Park, In Won; Park, Yong Bum; Park, So Young; Lee, Jaehee; Jung, Ki Suck.

In: Journal of Thoracic Disease, Vol. 7, No. 12, 01.01.2015, p. 2203-2213.

Research output: Contribution to journalArticle

Hwang, YI, Lee, SH, Yoo, JH, Jung, BH, Yoo, KH, Na, MJ, Lee, JD, Park, MJ, Jung, CY, Shim, JJ, Kim, KC, Kim, YJ, Choi, HS, Choi, IS, Lee, CT, Lee, SD, Kim, DJ, Uh, ST, Lee, HS, Kim, YS, Lee, KH, Ra, SW, Kim, HR, Choi, SJ, Park, IW, Park, YB, Park, SY, Lee, J & Jung, KS 2015, 'History of pneumonia is a strong risk factor for chronic obstructive pulmonary disease (COPD) exacerbation in South Korea: The Epidemiologic review and Prospective Observation of COPD and Health in Korea (EPOCH) study', Journal of Thoracic Disease, vol. 7, no. 12, pp. 2203-2213. https://doi.org/10.3978/j.issn.2072-1439.2015.12.17
Hwang, Yong Il ; Lee, Sang Haak ; Yoo, Jee Hong ; Jung, Bock Hyun ; Yoo, Kwang Ha ; Na, Moon Jun ; Lee, Jong Deog ; Park, Myung Jae ; Jung, Chi Young ; Shim, Jae Jeong ; Kim, Kyung Chan ; Kim, Yeon Jae ; Choi, Hye Sook ; Choi, Ik Su ; Lee, Choon Taek ; Lee, Sang Do ; Kim, Do Jin ; Uh, Soo Taek ; Lee, Ho Sung ; Kim, Young Sam ; Lee, Kwan Ho ; Ra, Seung Won ; Kim, Hak Ryul ; Choi, Soo Jeon ; Park, In Won ; Park, Yong Bum ; Park, So Young ; Lee, Jaehee ; Jung, Ki Suck. / History of pneumonia is a strong risk factor for chronic obstructive pulmonary disease (COPD) exacerbation in South Korea : The Epidemiologic review and Prospective Observation of COPD and Health in Korea (EPOCH) study. In: Journal of Thoracic Disease. 2015 ; Vol. 7, No. 12. pp. 2203-2213.
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abstract = "Background: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPD patients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPD patients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. Methods: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. Results: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8{\%}) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. Conclusions: This study examined the demographic and clinical characteristics of South Korean COPD patients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.",
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T1 - History of pneumonia is a strong risk factor for chronic obstructive pulmonary disease (COPD) exacerbation in South Korea

T2 - The Epidemiologic review and Prospective Observation of COPD and Health in Korea (EPOCH) study

AU - Hwang, Yong Il

AU - Lee, Sang Haak

AU - Yoo, Jee Hong

AU - Jung, Bock Hyun

AU - Yoo, Kwang Ha

AU - Na, Moon Jun

AU - Lee, Jong Deog

AU - Park, Myung Jae

AU - Jung, Chi Young

AU - Shim, Jae Jeong

AU - Kim, Kyung Chan

AU - Kim, Yeon Jae

AU - Choi, Hye Sook

AU - Choi, Ik Su

AU - Lee, Choon Taek

AU - Lee, Sang Do

AU - Kim, Do Jin

AU - Uh, Soo Taek

AU - Lee, Ho Sung

AU - Kim, Young Sam

AU - Lee, Kwan Ho

AU - Ra, Seung Won

AU - Kim, Hak Ryul

AU - Choi, Soo Jeon

AU - Park, In Won

AU - Park, Yong Bum

AU - Park, So Young

AU - Lee, Jaehee

AU - Jung, Ki Suck

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPD patients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPD patients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. Methods: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. Results: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8%) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. Conclusions: This study examined the demographic and clinical characteristics of South Korean COPD patients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.

AB - Background: In South Korea, chronic obstructive pulmonary disease (COPD) is one of the ten leading causes of death. COPD exacerbations are significantly associated with mortality in COPD patients. This study was conducted to investigate the epidemiology of COPD in South Korea, specifically the clinical characteristics of South Korean COPD patients, the COPD exacerbation rate and the risk factors associated with COPD exacerbations. Methods: This study covers a 2-year interval. One year was data collected retrospectively and the second year was prospectively obtained data. Results: A total of 1,114 subjects were enrolled in the study. These subjects were observed for a period of 1 year from the enrollment, and a total of 920 subjects completed the study. A total of 1,357 COPD exacerbations occurred in 711 subjects (63.8%) out of the total of 1,114 subjects during the study period of 2 years. Multivariate logistic regression results showed that if patients had had a pneumonia before the retrospective year of analysis, they had a 18 times greater chance of having an exacerbation during the prospective year when other variables were controlled. Also, the subjects who had a history of two or more exacerbations during the retrospective year were approximately 6 times more likely to experience the COPD exacerbation compared to those who did not. Conclusions: This study examined the demographic and clinical characteristics of South Korean COPD patients and found that a history of pneumonia and two or more occurrences of exacerbation within 1 year was significantly associated with a higher rate of COPD exacerbation.

KW - Chronic bronchitis

KW - Chronic obstructive pulmonary disease (COPD)

KW - Exacerbation

KW - Pneumonia

KW - South Korea

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