Hoffmann’s disease: MR imaging of hypothyroid myopathy

Jeewon Chung, Kyung Sik Ahn, Chang Ho Kang, Suk Joo Hong, Baek Hyun Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Hoffmann’s syndrome is a hypothyroid myopathy presenting as muscle stiffness and hypertrophy. It is a rare complication of hypothyroidism. MRI features of this syndrome have seldom been described in the literature. We present a case of Hoffmann’s syndrome in a 34-year-old man who underwent lower extremity contrast-enhanced MRI. MRI can demonstrate the hypertrophic configuration, T2 hyperintensity, and enhancement of the involved muscles in Hoffmann’s syndrome. Along with clinical, laboratory, and electromyography findings, MRI may be helpful in distinguishing between inflammatory myopathy, myonecrosis, subacute muscle denervation, and infectious myositis.

Original languageEnglish
Pages (from-to)1701-1704
Number of pages4
JournalSkeletal Radiology
Issue number11
Publication statusPublished - 2015 Nov 26


  • Hoffmann’s syndrome
  • Hypothyroidism
  • Magnetic resonance imaging
  • Myopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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