Hollow porous poly(ε-caprolactone) microspheres by emulsion solvent extraction

Tae Sik Jang; Eun Jung Lee; Hyoun Ee Kim; Young Hag Koh

doi:10.1016/j.matlet.2011.12.105

Hollow porous poly(ε-caprolactone) microspheres by emulsion solvent extraction

Tae Sik Jang, Eun Jung Lee, Hyoun Ee Kim, Young Hag Koh

School of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Hollow porous poly (ε-caprolactone) microspheres with different structures were prepared using a solvent/non-solvent emulsion solvent extraction technique. The PCL concentration is an important factor for controlling the structure of hollow PCL microspheres. Hollow PCL microspheres with a porous polymer shell were formed when the polymer concentration was appropriate (12% w/v), whereas porous microspheres were produced when the polymer concentration was too high (20% w/v). The ability to incorporate silica xerogels into the PCL hollow microspheres was examined by scanning electron microscopy. These PCL hollow porous microspheres have potential applications in the local delivery of proteins and drugs.

Original language	English
Pages (from-to)	157-159
Number of pages	3
Journal	Materials Letters
Volume	72
DOIs	https://doi.org/10.1016/j.matlet.2011.12.105
Publication status	Published - 2012 Apr 1

Keywords

Biodegradable
Hollow microsphere
Poly(ε-caprolactone)
Porous

ASJC Scopus subject areas

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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title = "Hollow porous poly(ε-caprolactone) microspheres by emulsion solvent extraction",

abstract = "Hollow porous poly (ε-caprolactone) microspheres with different structures were prepared using a solvent/non-solvent emulsion solvent extraction technique. The PCL concentration is an important factor for controlling the structure of hollow PCL microspheres. Hollow PCL microspheres with a porous polymer shell were formed when the polymer concentration was appropriate (12% w/v), whereas porous microspheres were produced when the polymer concentration was too high (20% w/v). The ability to incorporate silica xerogels into the PCL hollow microspheres was examined by scanning electron microscopy. These PCL hollow porous microspheres have potential applications in the local delivery of proteins and drugs.",

keywords = "Biodegradable, Hollow microsphere, Poly(ε-caprolactone), Porous",

author = "Jang, {Tae Sik} and Lee, {Eun Jung} and Kim, {Hyoun Ee} and Koh, {Young Hag}",

note = "Funding Information: This work was supported by the Technology Innovation Program (Contract No. 10037915 , WPM Biomedical Materials–Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea) . Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

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AU - Lee, Eun Jung

AU - Kim, Hyoun Ee

AU - Koh, Young Hag

N1 - Funding Information: This work was supported by the Technology Innovation Program (Contract No. 10037915 , WPM Biomedical Materials–Implant Materials) funded by the Ministry of Knowledge Economy (MKE, Korea) . Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Hollow porous poly (ε-caprolactone) microspheres with different structures were prepared using a solvent/non-solvent emulsion solvent extraction technique. The PCL concentration is an important factor for controlling the structure of hollow PCL microspheres. Hollow PCL microspheres with a porous polymer shell were formed when the polymer concentration was appropriate (12% w/v), whereas porous microspheres were produced when the polymer concentration was too high (20% w/v). The ability to incorporate silica xerogels into the PCL hollow microspheres was examined by scanning electron microscopy. These PCL hollow porous microspheres have potential applications in the local delivery of proteins and drugs.

AB - Hollow porous poly (ε-caprolactone) microspheres with different structures were prepared using a solvent/non-solvent emulsion solvent extraction technique. The PCL concentration is an important factor for controlling the structure of hollow PCL microspheres. Hollow PCL microspheres with a porous polymer shell were formed when the polymer concentration was appropriate (12% w/v), whereas porous microspheres were produced when the polymer concentration was too high (20% w/v). The ability to incorporate silica xerogels into the PCL hollow microspheres was examined by scanning electron microscopy. These PCL hollow porous microspheres have potential applications in the local delivery of proteins and drugs.

KW - Biodegradable

KW - Hollow microsphere

KW - Poly(ε-caprolactone)

KW - Porous

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JO - Materials Letters

JF - Materials Letters

SN - 0167-577X

ER -

Hollow porous poly(ε-caprolactone) microspheres by emulsion solvent extraction

Abstract

Keywords

ASJC Scopus subject areas

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