Hollow Pt-Functionalized SnO2 Hemipill Network Formation Using a Bacterial Skeleton for the Noninvasive Diagnosis of Diabetes

Hi Gyu Moon, Youngmo Jung, Dukwoo Jun, Ji Hyun Park, Young Wook Chang, Hyung Ho Park, Chong-Yun Kang, Chulki Kim, Richard B. Kaner

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hollow-structured nanomaterials are presented as an outstanding sensing platform because of their unique combination of high porosity in both the micro- and nanoscale, their biocompatibility, and flexible template applicability. Herein, we introduce a bacterial skeleton method allowing for cost-effective fabrication with nanoscale precision. As a proof-of-concept, we fabricated a hollow SnO2 hemipill network (HSHN) and a hollow Pt-functionalized SnO2 hemipill network (HPN). A superior detecting capability of HPN toward acetone, a diabetes biomarker, was demonstrated at low concentration (200 ppb) under high humidity (RH 80%). The detection limit reaches 3.6 ppb, a level satisfying the minimum requirement for diabetes breath diagnosis. High selectivity of the HPN sensor against C6H6, C7H8, CO, and NO vapors is demonstrated using principal component analysis (PCA), suggesting new applications of HPN for human-activity monitoring and a personal healthcare tool for diagnosing diabetes. The skeleton method can be further employed to mimic nanostructures of biomaterials with unique functionality for broad applications.

Original languageEnglish
Pages (from-to)661-669
Number of pages9
JournalACS Sensors
Volume3
Issue number3
DOIs
Publication statusPublished - 2018 Mar 23
Externally publishedYes

Fingerprint

Medical problems
musculoskeletal system
hollow
Biocompatible Materials
Biomarkers
Carbon Monoxide
Acetone
Biocompatibility
Nanostructured materials
Biomaterials
Principal component analysis
Sensor networks
Nanostructures
Atmospheric humidity
Porosity
Vapors
biomarkers
Fabrication
biocompatibility
principal components analysis

Keywords

  • bacterial skeleton
  • chemiresisitve sensor
  • diabetes
  • exhaled breath analyzer
  • hollow SnO nanostructures

ASJC Scopus subject areas

  • Bioengineering
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Instrumentation

Cite this

Hollow Pt-Functionalized SnO2 Hemipill Network Formation Using a Bacterial Skeleton for the Noninvasive Diagnosis of Diabetes. / Moon, Hi Gyu; Jung, Youngmo; Jun, Dukwoo; Park, Ji Hyun; Chang, Young Wook; Park, Hyung Ho; Kang, Chong-Yun; Kim, Chulki; Kaner, Richard B.

In: ACS Sensors, Vol. 3, No. 3, 23.03.2018, p. 661-669.

Research output: Contribution to journalArticle

Moon, HG, Jung, Y, Jun, D, Park, JH, Chang, YW, Park, HH, Kang, C-Y, Kim, C & Kaner, RB 2018, 'Hollow Pt-Functionalized SnO2 Hemipill Network Formation Using a Bacterial Skeleton for the Noninvasive Diagnosis of Diabetes', ACS Sensors, vol. 3, no. 3, pp. 661-669. https://doi.org/10.1021/acssensors.7b00955
Moon, Hi Gyu ; Jung, Youngmo ; Jun, Dukwoo ; Park, Ji Hyun ; Chang, Young Wook ; Park, Hyung Ho ; Kang, Chong-Yun ; Kim, Chulki ; Kaner, Richard B. / Hollow Pt-Functionalized SnO2 Hemipill Network Formation Using a Bacterial Skeleton for the Noninvasive Diagnosis of Diabetes. In: ACS Sensors. 2018 ; Vol. 3, No. 3. pp. 661-669.
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