Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Kwangyeol Lee, Jin Suck Suh, Ho Geun Yoon, Yong Mip Huh, Seungjoo Haam

Research output: Contribution to journalArticle

214 Citations (Scopus)

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Original languageEnglish
Pages (from-to)3417-3421
Number of pages5
JournalLangmuir
Volume24
Issue number7
DOIs
Publication statusPublished - 2008 Apr 1

Fingerprint

Drug delivery
Silicon Dioxide
Nanoparticles
hollow
delivery
vehicles
drugs
Silica
silicon dioxide
nanoparticles
Pharmaceutical Preparations
Hydrochloric Acid
hydrochloric acid
Hydrochloric acid
Surface charge
Calcination
roasting
Doxorubicin
Solubility
Nanocrystals

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Yang, J., Lee, J., Kang, J., Lee, K., Suh, J. S., Yoon, H. G., ... Haam, S. (2008). Hollow silica nanocontainers as drug delivery vehicles. Langmuir, 24(7), 3417-3421. https://doi.org/10.1021/la701688t

Hollow silica nanocontainers as drug delivery vehicles. / Yang, Jaemoon; Lee, Jaewon; Kang, Jinyoung; Lee, Kwangyeol; Suh, Jin Suck; Yoon, Ho Geun; Huh, Yong Mip; Haam, Seungjoo.

In: Langmuir, Vol. 24, No. 7, 01.04.2008, p. 3417-3421.

Research output: Contribution to journalArticle

Yang, J, Lee, J, Kang, J, Lee, K, Suh, JS, Yoon, HG, Huh, YM & Haam, S 2008, 'Hollow silica nanocontainers as drug delivery vehicles', Langmuir, vol. 24, no. 7, pp. 3417-3421. https://doi.org/10.1021/la701688t
Yang J, Lee J, Kang J, Lee K, Suh JS, Yoon HG et al. Hollow silica nanocontainers as drug delivery vehicles. Langmuir. 2008 Apr 1;24(7):3417-3421. https://doi.org/10.1021/la701688t
Yang, Jaemoon ; Lee, Jaewon ; Kang, Jinyoung ; Lee, Kwangyeol ; Suh, Jin Suck ; Yoon, Ho Geun ; Huh, Yong Mip ; Haam, Seungjoo. / Hollow silica nanocontainers as drug delivery vehicles. In: Langmuir. 2008 ; Vol. 24, No. 7. pp. 3417-3421.
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