Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Kwangyeol Lee, Jin Suck Suh, Ho Geun Yoon, Yong Mip Huh, Seungjoo Haam

Research output: Contribution to journalArticle

221 Citations (Scopus)

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Original languageEnglish
Pages (from-to)3417-3421
Number of pages5
JournalLangmuir
Volume24
Issue number7
DOIs
Publication statusPublished - 2008 Apr 1

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Yang, J., Lee, J., Kang, J., Lee, K., Suh, J. S., Yoon, H. G., Huh, Y. M., & Haam, S. (2008). Hollow silica nanocontainers as drug delivery vehicles. Langmuir, 24(7), 3417-3421. https://doi.org/10.1021/la701688t