homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer

Sung Woo Jung, Mitsushige Sugimoto, David Y. Graham, Yoshio Yamaoka

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the homB gene was significantly higher in strains isolated from gastric-cancer patients (71.9%) than in those from duodenal ulcer patients (52.1%) (P = 0.012). In a multivariate analysis, the presence of the cagA gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the homB gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95% confidence interval, ∼1.37 to ∼6.73). cagA status was correlated with homB status (r = 0.323; P < 0.01). A histological analysis showed that cagA status was associated with inflammation and atrophy both in the antrum and in the corpus, while homB status was associated with inflammation and atrophy in the corpus. homB gene status might be susceptible to gastric-cancer development such that the homB gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.

Original languageEnglish
Pages (from-to)3241-3245
Number of pages5
JournalJournal of Clinical Microbiology
Volume47
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

Fingerprint

Duodenal Ulcer
Helicobacter pylori
Stomach Neoplasms
Genes
Atrophy
Inflammation
Virulence Factors
Gastritis
Stomach Ulcer
Stomach
Membrane Proteins
Multivariate Analysis
Odds Ratio
Confidence Intervals
Polymerase Chain Reaction
Wounds and Injuries
Population

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer. / Jung, Sung Woo; Sugimoto, Mitsushige; Graham, David Y.; Yamaoka, Yoshio.

In: Journal of Clinical Microbiology, Vol. 47, No. 10, 01.10.2009, p. 3241-3245.

Research output: Contribution to journalArticle

Jung, Sung Woo ; Sugimoto, Mitsushige ; Graham, David Y. ; Yamaoka, Yoshio. / homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer. In: Journal of Clinical Microbiology. 2009 ; Vol. 47, No. 10. pp. 3241-3245.
@article{2cd0c572aa074fbfa0405ee5035231c3,
title = "homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer",
abstract = "The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the homB gene was significantly higher in strains isolated from gastric-cancer patients (71.9{\%}) than in those from duodenal ulcer patients (52.1{\%}) (P = 0.012). In a multivariate analysis, the presence of the cagA gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the homB gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95{\%} confidence interval, ∼1.37 to ∼6.73). cagA status was correlated with homB status (r = 0.323; P < 0.01). A histological analysis showed that cagA status was associated with inflammation and atrophy both in the antrum and in the corpus, while homB status was associated with inflammation and atrophy in the corpus. homB gene status might be susceptible to gastric-cancer development such that the homB gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.",
author = "Jung, {Sung Woo} and Mitsushige Sugimoto and Graham, {David Y.} and Yoshio Yamaoka",
year = "2009",
month = "10",
day = "1",
doi = "10.1128/JCM.00293-09",
language = "English",
volume = "47",
pages = "3241--3245",
journal = "Journal of Clinical Microbiology",
issn = "0095-1137",
publisher = "American Society for Microbiology",
number = "10",

}

TY - JOUR

T1 - homB status of Helicobacter pylori as a novel marker to distinguish gastric cancer from duodenal ulcer

AU - Jung, Sung Woo

AU - Sugimoto, Mitsushige

AU - Graham, David Y.

AU - Yamaoka, Yoshio

PY - 2009/10/1

Y1 - 2009/10/1

N2 - The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the homB gene was significantly higher in strains isolated from gastric-cancer patients (71.9%) than in those from duodenal ulcer patients (52.1%) (P = 0.012). In a multivariate analysis, the presence of the cagA gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the homB gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95% confidence interval, ∼1.37 to ∼6.73). cagA status was correlated with homB status (r = 0.323; P < 0.01). A histological analysis showed that cagA status was associated with inflammation and atrophy both in the antrum and in the corpus, while homB status was associated with inflammation and atrophy in the corpus. homB gene status might be susceptible to gastric-cancer development such that the homB gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.

AB - The hom family of Helicobacter pylori outer-membrane proteins, especially the homB gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the homA, homB, and cagA genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the homB gene was significantly higher in strains isolated from gastric-cancer patients (71.9%) than in those from duodenal ulcer patients (52.1%) (P = 0.012). In a multivariate analysis, the presence of the cagA gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the homB gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95% confidence interval, ∼1.37 to ∼6.73). cagA status was correlated with homB status (r = 0.323; P < 0.01). A histological analysis showed that cagA status was associated with inflammation and atrophy both in the antrum and in the corpus, while homB status was associated with inflammation and atrophy in the corpus. homB gene status might be susceptible to gastric-cancer development such that the homB gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.

UR - http://www.scopus.com/inward/record.url?scp=70349646996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349646996&partnerID=8YFLogxK

U2 - 10.1128/JCM.00293-09

DO - 10.1128/JCM.00293-09

M3 - Article

C2 - 19710266

AN - SCOPUS:70349646996

VL - 47

SP - 3241

EP - 3245

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

IS - 10

ER -