Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer

Myung Woul Han, Jong Cheol Lee, Seung Yoon Park, Young Min Kim, Kyung Ja Cho, Seong Who Kim, Myungjin Lee, Soon Yuhl Nam, In-San Kim, Sang Yoon Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aim: Lymph node (LN) metastasis of solid types of tumors has important clinical significance and it is therefore critical to identify molecular biomarkers that would enable the selection of patients with LN metastases. Patients and Methods: We evaluated the expression of stabilin-2 in primary oral tongue tumors and metastatic LNs using immunohistochemical staining. The correlation between risk factors and nodal metastasis was assessed and disease-free survival was analyzed. Results: Stabilin-2 expression remained a significant predictor of LN metastasis and the factor affecting recurrence in tongue cancer. Most importantly, all metastatic tumors of tongue, lung, stomach and colon cancers stained positive for stabilin-2 and stabilin-2 was expressed strongly in the sinusoidal endothelial cell of metastatic LNs. Conclusion: Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors.

Original languageEnglish
Pages (from-to)6611-6618
Number of pages8
JournalAnticancer research
Volume36
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

Fingerprint

Tongue Neoplasms
Lymph Nodes
Neoplasm Metastasis
Neoplasms
Lymphatic Endothelium
Tumor Biomarkers
Tongue
Colonic Neoplasms
Patient Selection
Disease-Free Survival
Stomach Neoplasms
Lung Neoplasms
Endothelial Cells
Biomarkers
Staining and Labeling
Recurrence

Keywords

  • Lymph node metastasis
  • Lymphatic endothelial cells
  • Stabilin-2
  • Tongue cancer
  • Tumor biomarker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Han, M. W., Lee, J. C., Park, S. Y., Kim, Y. M., Cho, K. J., Kim, S. W., ... Kim, S. Y. (2016). Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer. Anticancer research, 36(12), 6611-6618. https://doi.org/10.21873/anticanres.11267

Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer. / Han, Myung Woul; Lee, Jong Cheol; Park, Seung Yoon; Kim, Young Min; Cho, Kyung Ja; Kim, Seong Who; Lee, Myungjin; Nam, Soon Yuhl; Kim, In-San; Kim, Sang Yoon.

In: Anticancer research, Vol. 36, No. 12, 01.12.2016, p. 6611-6618.

Research output: Contribution to journalArticle

Han, MW, Lee, JC, Park, SY, Kim, YM, Cho, KJ, Kim, SW, Lee, M, Nam, SY, Kim, I-S & Kim, SY 2016, 'Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer', Anticancer research, vol. 36, no. 12, pp. 6611-6618. https://doi.org/10.21873/anticanres.11267
Han, Myung Woul ; Lee, Jong Cheol ; Park, Seung Yoon ; Kim, Young Min ; Cho, Kyung Ja ; Kim, Seong Who ; Lee, Myungjin ; Nam, Soon Yuhl ; Kim, In-San ; Kim, Sang Yoon. / Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer. In: Anticancer research. 2016 ; Vol. 36, No. 12. pp. 6611-6618.
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AB - Background/Aim: Lymph node (LN) metastasis of solid types of tumors has important clinical significance and it is therefore critical to identify molecular biomarkers that would enable the selection of patients with LN metastases. Patients and Methods: We evaluated the expression of stabilin-2 in primary oral tongue tumors and metastatic LNs using immunohistochemical staining. The correlation between risk factors and nodal metastasis was assessed and disease-free survival was analyzed. Results: Stabilin-2 expression remained a significant predictor of LN metastasis and the factor affecting recurrence in tongue cancer. Most importantly, all metastatic tumors of tongue, lung, stomach and colon cancers stained positive for stabilin-2 and stabilin-2 was expressed strongly in the sinusoidal endothelial cell of metastatic LNs. Conclusion: Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors.

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