Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer

Myung Woul Han, Jong Cheol Lee, Seung Yoon Park, Young Min Kim, Kyung Ja Cho, Seong Who Kim, Myungjin Lee, Soon Yuhl Nam, In-San Kim, Sang Yoon Kim

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1 Citation (Scopus)

Abstract

Background/Aim: Lymph node (LN) metastasis of solid types of tumors has important clinical significance and it is therefore critical to identify molecular biomarkers that would enable the selection of patients with LN metastases. Patients and Methods: We evaluated the expression of stabilin-2 in primary oral tongue tumors and metastatic LNs using immunohistochemical staining. The correlation between risk factors and nodal metastasis was assessed and disease-free survival was analyzed. Results: Stabilin-2 expression remained a significant predictor of LN metastasis and the factor affecting recurrence in tongue cancer. Most importantly, all metastatic tumors of tongue, lung, stomach and colon cancers stained positive for stabilin-2 and stabilin-2 was expressed strongly in the sinusoidal endothelial cell of metastatic LNs. Conclusion: Stabilin-2 can play a critical role in the first entrapping step of LN metastasis through homotypic interaction with the lymphatic endothelium and appears to be a tumor biomarker predicting for LN metastasis in patients with solid tumors.

Original languageEnglish
Pages (from-to)6611-6618
Number of pages8
JournalAnticancer research
Volume36
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

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Keywords

  • Lymph node metastasis
  • Lymphatic endothelial cells
  • Stabilin-2
  • Tongue cancer
  • Tumor biomarker

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Han, M. W., Lee, J. C., Park, S. Y., Kim, Y. M., Cho, K. J., Kim, S. W., Lee, M., Nam, S. Y., Kim, I-S., & Kim, S. Y. (2016). Homotypic interaction of stabilin-2 plays a critical role in lymph node metastasis of tongue cancer. Anticancer research, 36(12), 6611-6618. https://doi.org/10.21873/anticanres.11267