Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young-Gyu Ko, Woo Je Lee, Ki Up Lee, Young Il Yeom, Sunghoon Kim

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

Original languageEnglish
Pages (from-to)14913-14918
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number40
DOIs
Publication statusPublished - 2006 Oct 3

Fingerprint

Homeostasis
Glucagon
Glucose
Starvation
Wound Healing
Pancreas
Fasting
Fatty Acids
Cytokines
Inflammation

Keywords

  • Aminoacyl-tRNA synthetase
  • Glucagon
  • Pancreas

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Hormonal activity of AIMP1/p43 for glucose homeostasis. / Park, Sang Gyu; Kang, Young Sun; Kim, Jin Young; Lee, Chang Seok; Ko, Young-Gyu; Lee, Woo Je; Lee, Ki Up; Yeom, Young Il; Kim, Sunghoon.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 40, 03.10.2006, p. 14913-14918.

Research output: Contribution to journalArticle

Park, SG, Kang, YS, Kim, JY, Lee, CS, Ko, Y-G, Lee, WJ, Lee, KU, Yeom, YI & Kim, S 2006, 'Hormonal activity of AIMP1/p43 for glucose homeostasis', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 40, pp. 14913-14918. https://doi.org/10.1073/pnas.0602045103
Park, Sang Gyu ; Kang, Young Sun ; Kim, Jin Young ; Lee, Chang Seok ; Ko, Young-Gyu ; Lee, Woo Je ; Lee, Ki Up ; Yeom, Young Il ; Kim, Sunghoon. / Hormonal activity of AIMP1/p43 for glucose homeostasis. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 40. pp. 14913-14918.
@article{ae37ddc59ca14a71bd701d07ca6806e5,
title = "Hormonal activity of AIMP1/p43 for glucose homeostasis",
abstract = "AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.",
keywords = "Aminoacyl-tRNA synthetase, Glucagon, Pancreas",
author = "Park, {Sang Gyu} and Kang, {Young Sun} and Kim, {Jin Young} and Lee, {Chang Seok} and Young-Gyu Ko and Lee, {Woo Je} and Lee, {Ki Up} and Yeom, {Young Il} and Sunghoon Kim",
year = "2006",
month = "10",
day = "3",
doi = "10.1073/pnas.0602045103",
language = "English",
volume = "103",
pages = "14913--14918",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "40",

}

TY - JOUR

T1 - Hormonal activity of AIMP1/p43 for glucose homeostasis

AU - Park, Sang Gyu

AU - Kang, Young Sun

AU - Kim, Jin Young

AU - Lee, Chang Seok

AU - Ko, Young-Gyu

AU - Lee, Woo Je

AU - Lee, Ki Up

AU - Yeom, Young Il

AU - Kim, Sunghoon

PY - 2006/10/3

Y1 - 2006/10/3

N2 - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

AB - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

KW - Aminoacyl-tRNA synthetase

KW - Glucagon

KW - Pancreas

UR - http://www.scopus.com/inward/record.url?scp=33749532843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749532843&partnerID=8YFLogxK

U2 - 10.1073/pnas.0602045103

DO - 10.1073/pnas.0602045103

M3 - Article

C2 - 17001013

AN - SCOPUS:33749532843

VL - 103

SP - 14913

EP - 14918

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 40

ER -