Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki Up Lee, Young Il Yeom, Sunghoon Kim

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

Original languageEnglish
Pages (from-to)14913-14918
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number40
DOIs
Publication statusPublished - 2006 Oct 3

Keywords

  • Aminoacyl-tRNA synthetase
  • Glucagon
  • Pancreas

ASJC Scopus subject areas

  • General

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  • Cite this

    Park, S. G., Kang, Y. S., Kim, J. Y., Lee, C. S., Ko, Y. G., Lee, W. J., Lee, K. U., Yeom, Y. I., & Kim, S. (2006). Hormonal activity of AIMP1/p43 for glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 103(40), 14913-14918. https://doi.org/10.1073/pnas.0602045103