Hornerin is involved in breast cancer progression

Jinhyuk Choi, Dong Il Kim, Jinkyoung Kim, Baek Hui Kim, Aeree Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The S100 gene family, which comprises over 20 members, including S100A1, S100A2, S100A8, S100A9, profilaggrin, and hornerin encodes low molecular weight calcium-binding proteins with physiological and pathological roles in keratinization. Recent studies have suggested a link between S100 proteins and human cancer progression. The purpose of the present study was to determine the expression levels of hornerin, S100A8, and S100A9 and evaluate their roles in the progression of invasive ductal carcinoma (IDC). Methods: Seventy cases of ductal carcinoma in situ (DCIS), IDC, and metastatic carcinoma in lymph nodes (MCN) were included. Tissue microarrays were constructed from lesions of DCIS, IDC, and MCN from the same patients. Expression of hornerin, S100A8, and S100A9 was analyzed using immunohistochemistry. Results: The expression of hornerin was associated with the estrogen receptor-negative (p=0.003) and the human epidermal growth factor receptor 2-positive (p=0.002) groups. The expression of S100A8 was associated with a higher pT stage (p=0.017). A significant (p<0.001) correlation between the expression of S100A9 and S100A8 was also found. The mean percentages of hornerinpositive tumor cells in DCIS, IDC, and MCN were 1.0%±3.3% (mean±standard deviation), 12.0%±24.0%, and 75.3%± 27.6%, respectively. The expression of hornerin significantly (p<0.001) increased with the progression of carcinoma. The mean levels of S100A8 and S100A9 in DCIS, IDC, and MCN were not significantly (p>0.050) different. The expression of hornerin increased in a stepwise manner (DCIS<IDC<MCN). Conclusion: Our data suggest that hornerin is involved in breast cancer progression and malignant transformation from preinvasive lesions.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalJournal of Breast Cancer
Volume19
Issue number2
DOIs
Publication statusPublished - 2016 Jun

Keywords

  • Breast neoplasms
  • Hornerin protein
  • S100 proteins

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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