Hot channels in airways

Pharmacology of the vanilloid receptor

Sun Wook Hwang, Uhtaek Oh

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume2
Issue number3
DOIs
Publication statusPublished - 2002 Jun 1
Externally publishedYes

Fingerprint

TRPV Cation Channels
Asthma
Pharmacology
Nociceptors
Lipoxygenase
Type C Phospholipases
Bradykinin
Protein Kinase C
Cations
TRPV1 receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Hot channels in airways : Pharmacology of the vanilloid receptor. / Hwang, Sun Wook; Oh, Uhtaek.

In: Current Opinion in Pharmacology, Vol. 2, No. 3, 01.06.2002, p. 235-242.

Research output: Contribution to journalArticle

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