Hot channels in airways: Pharmacology of the vanilloid receptor

Sun Wook Hwang, Uhtaek Oh

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)


Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalCurrent Opinion in Pharmacology
Issue number3
Publication statusPublished - 2002 Jun 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


Dive into the research topics of 'Hot channels in airways: Pharmacology of the vanilloid receptor'. Together they form a unique fingerprint.

Cite this