Abstract
Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 235-242 |
| Number of pages | 8 |
| Journal | Current Opinion in Pharmacology |
| Volume | 2 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2002 Jun 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Hot channels in airways : Pharmacology of the vanilloid receptor. / Hwang, Sun Wook; Oh, Uhtaek.
In: Current Opinion in Pharmacology, Vol. 2, No. 3, 01.06.2002, p. 235-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hot channels in airways
T2 - Pharmacology of the vanilloid receptor
AU - Hwang, Sun Wook
AU - Oh, Uhtaek
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.
AB - Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.
UR - http://www.scopus.com/inward/record.url?scp=0036605663&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036605663&partnerID=8YFLogxK
U2 - 10.1016/S1471-4892(02)00149-2
DO - 10.1016/S1471-4892(02)00149-2
M3 - Article
C2 - 12020463
AN - SCOPUS:0036605663
VL - 2
SP - 235
EP - 242
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
IS - 3
ER -