Human CC chemokine CCL23, a ligand for CCR1, induces endothelial cell migration and promotes angiogenesis

Jungsu Hwang, Kyung No Son, Woo Kim Chan, Jesang Ko, Sun Na Doe, Byoung S. Kwon, Song Gho Yong, Jiyoung Kim

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

A number of chemokines induce angiogenesis and endothelial cells express several chemokine receptors. To date, only a limited number of CC chemokines for CCR1 have been reported to induce angiogenic responses. We investigated the ability of CCL23 (also known as MPIF-1, MIP-3, or CKβ8) to promote angiogenesis, which induces chemotaxis of immune cells through CCR1. CCL23 promoted the chemotactic migration and differentiation of endothelial cells, and neovascularization in the chick chorioallantoic membrane. An N-terminal truncated form of CCL23 was at least 100-fold more potent than its intact form and was comparable to that of FGF in the angiogenic activities. Treatment with either pertussis toxin or anti-CCR1 antibody completely inhibited the CCL23-induced endothelial cell migration, indicating that endothelial cell migration was mediated through CCR1. CCL23 didn't promote the migration of HT1080 human fibrosarcoma cells that did not express CCR1. Our results suggest a role of CCL23 in angiogenesis in vitro as well as in vivo.

Original languageEnglish
Pages (from-to)254-263
Number of pages10
JournalCytokine
Volume30
Issue number5
DOIs
Publication statusPublished - 2005 Jun 7
Externally publishedYes

Keywords

  • Angiogenesis
  • CCL23
  • CCR1
  • CKβ8
  • Chemokine
  • Endothelial cells
  • MIP-3
  • MPIF-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

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