Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study

Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon-Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, Jun Yong Choi

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5 Citations (Scopus)

Abstract

Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalInfection and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • Coinfection
  • Hepatitis B virus
  • Hepatitis C virus
  • HIV infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Kim, Y. C., Ahn, J. Y., Kim, J. M., Kim, Y. J., Park, D. W., Yoon, Y. K., Song, J-Y., Kim, S. W., Lee, J. S., Choi, B. Y., Choi, Y. S., Choi, J. Y., Han, M. G., Kang, C., & Choi, J. Y. (2017). Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study. Infection and Chemotherapy, 49(4), 268-274. https://doi.org/10.3947/ic.2017.49.4.268