Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients: The Korea HIV/AIDS cohort study

Yong Chan Kim, Jin Young Ahn, June Myung Kim, Youn Jeong Kim, Dae Won Park, Young Kyung Yoon, Joon-Young Song, Shin Woo Kim, Jin Soo Lee, Bo Youl Choi, Yun Su Choi, Ju Yeon Choi, Myung Guk Han, Chun Kang, Jun Yong Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

Original languageEnglish
Pages (from-to)268-274
Number of pages7
JournalInfection and Chemotherapy
Volume49
Issue number4
DOIs
Publication statusPublished - 2017 Dec 1

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Hepatitis Viruses
Korea
Coinfection
Acquired Immunodeficiency Syndrome
Cohort Studies
HIV
Hepatitis B virus
Hepacivirus
Virus Diseases
Hepatitis C Antibodies
Highly Active Antiretroviral Therapy
Chronic Hepatitis B
HIV-1
Liver Diseases
Cause of Death
Cross-Sectional Studies
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Coinfection
  • Hepatitis B virus
  • Hepatitis C virus
  • HIV infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients : The Korea HIV/AIDS cohort study. / Kim, Yong Chan; Ahn, Jin Young; Kim, June Myung; Kim, Youn Jeong; Park, Dae Won; Yoon, Young Kyung; Song, Joon-Young; Kim, Shin Woo; Lee, Jin Soo; Choi, Bo Youl; Choi, Yun Su; Choi, Ju Yeon; Han, Myung Guk; Kang, Chun; Choi, Jun Yong.

In: Infection and Chemotherapy, Vol. 49, No. 4, 01.12.2017, p. 268-274.

Research output: Contribution to journalArticle

Kim, Yong Chan ; Ahn, Jin Young ; Kim, June Myung ; Kim, Youn Jeong ; Park, Dae Won ; Yoon, Young Kyung ; Song, Joon-Young ; Kim, Shin Woo ; Lee, Jin Soo ; Choi, Bo Youl ; Choi, Yun Su ; Choi, Ju Yeon ; Han, Myung Guk ; Kang, Chun ; Choi, Jun Yong. / Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients : The Korea HIV/AIDS cohort study. In: Infection and Chemotherapy. 2017 ; Vol. 49, No. 4. pp. 268-274.
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T1 - Human immunodeficiency virus (HIV) and hepatitis virus coinfection among HIV-infected Korean patients

T2 - The Korea HIV/AIDS cohort study

AU - Kim, Yong Chan

AU - Ahn, Jin Young

AU - Kim, June Myung

AU - Kim, Youn Jeong

AU - Park, Dae Won

AU - Yoon, Young Kyung

AU - Song, Joon-Young

AU - Kim, Shin Woo

AU - Lee, Jin Soo

AU - Choi, Bo Youl

AU - Choi, Yun Su

AU - Choi, Ju Yeon

AU - Han, Myung Guk

AU - Kang, Chun

AU - Choi, Jun Yong

PY - 2017/12/1

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N2 - Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

AB - Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43-17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

KW - Coinfection

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - HIV infection

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