Human induced pluripotent stem cell line with cytochrome P450 enzyme polymorphism (CYP2C19*2/CYP3A5*3C) generated from lymphoblastoid cells

Jaehun Lee, Dong Hun Woo, Han Jin Park, Kijung Park, Duck Sung Ko, Jong-Hoon Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cytochrome P450 (CYP) comprises a superfamily of monooxygenase responsible for the metabolism of xenobiotics and approximately 75% of drugs in use today. Thus, genetic polymorphisms in CYP genes contribute to interindividual differences in hepatic metabolism of drugs, affecting on individual drug efficacy and may cause adverse effects. Here, we generated a human induced pluripotent stem cell (hiPSC) line with pharmacologically important traits (CYP2C19*2/CYP3A5*3C), which are highly polymorphic in Asian from lymphoblastoid cells. This hiPSC line could be a valuable source for predicting individual drug responses in the drug screening process that uses hiPSC-derived somatic cells, including hepatocytes.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalStem Cell Research
Volume27
DOIs
Publication statusPublished - 2018 Mar 1

Fingerprint

Cytochrome P-450 CYP3A
Induced Pluripotent Stem Cells
Cytochrome P-450 Enzyme System
Cell Line
Pharmaceutical Preparations
Preclinical Drug Evaluations
Xenobiotics
Genetic Polymorphisms
Mixed Function Oxygenases
Hepatocytes
Cytochrome P-450 CYP2C19
Liver
Genes

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Human induced pluripotent stem cell line with cytochrome P450 enzyme polymorphism (CYP2C19*2/CYP3A5*3C) generated from lymphoblastoid cells. / Lee, Jaehun; Woo, Dong Hun; Park, Han Jin; Park, Kijung; Ko, Duck Sung; Kim, Jong-Hoon.

In: Stem Cell Research, Vol. 27, 01.03.2018, p. 34-37.

Research output: Contribution to journalArticle

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