TY - JOUR
T1 - Human induced pluripotent stem cells
T2 - Clinical significance and applications in neurologic diseases
AU - Chang, Eun Ah
AU - Jin, Sung Won
AU - Nam, Myung Hyun
AU - Kim, Sang Dae
N1 - Funding Information:
This research was supported by the Korea University Medical Center (K1613701).
PY - 2019/9
Y1 - 2019/9
N2 - The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.
AB - The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.
KW - Cell-based therapy
KW - Induced pluripotent stem cells
KW - Precision medicine
UR - http://www.scopus.com/inward/record.url?scp=85073338348&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073338348&partnerID=8YFLogxK
U2 - 10.3340/jkns.2018.0222
DO - 10.3340/jkns.2018.0222
M3 - Review article
AN - SCOPUS:85073338348
VL - 62
SP - 493
EP - 501
JO - Journal of Korean Neurosurgical Society
JF - Journal of Korean Neurosurgical Society
SN - 2005-3711
IS - 5
ER -