Human induced pluripotent stem cells: Clinical significance and applications in neurologic diseases

Eun Ah Chang, Sung Won Jin, Myung Hyun Nam, Sang Dae Kim

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)

    Abstract

    The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.

    Original languageEnglish
    Pages (from-to)493-501
    Number of pages9
    JournalJournal of Korean Neurosurgical Society
    Volume62
    Issue number5
    DOIs
    Publication statusPublished - 2019 Sep

    Keywords

    • Cell-based therapy
    • Induced pluripotent stem cells
    • Precision medicine

    ASJC Scopus subject areas

    • Surgery
    • Neuroscience(all)
    • Clinical Neurology

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