Human induced pluripotent stem cells: Clinical significance and applications in neurologic diseases

Eun Ah Chang, Sung Won Jin, Myung Hyun Nam, Sang Dae Kim

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of essential platforms for targeted drug development. iPSCs retain the genome of the donor, may regenerate indefinitely, and undergo differentiation into virtually any cell type of interest using a range of published protocols. There has been enormous interest among researchers regarding the application of iPSC technology to regenerative medicine and human disease modeling, in particular, modeling of neurologic diseases using patient-specific iPSCs. For instance, Parkinson’s disease, Alzheimer’s disease, and spinal cord injuries may be treated with iPSC therapy or replacement tissues obtained from iPSCs. In this review, we discuss the work so far on generation and characterization of iPSCs and focus on recent advances in the use of human iPSCs in clinical setting.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalJournal of Korean Neurosurgical Society
Volume62
Issue number5
DOIs
Publication statusPublished - 2019 Sep

Keywords

  • Cell-based therapy
  • Induced pluripotent stem cells
  • Precision medicine

ASJC Scopus subject areas

  • Surgery
  • Neuroscience(all)
  • Clinical Neurology

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