Human infection with seoul orthohantavirus in Korea, 2019

Changmin Kang, Jin Il Kim, Jungmin Lee, Seongman Bae, Min Jae Kim, Ki Joon Song, Jin Won Song, Sung Han Kim, Man Seong Park

Research output: Contribution to journalArticlepeer-review


Of various rodent-borne hantaviruses, Seoul orthohantavirus (SEOV) causes haemorrhagic fever with renal syndrome (HFRS), as does Hantaan orthohantavirus (HTNV). Given global-scale of cases of human infection with SEOV, it is of great clinical importance to distinguish SEOV from other HFRS-causing hantaviruses. In May 2019, a middle-aged patient who had lived in a suburban area of Chungcheong Province, Republic of Korea and enjoyed outdoor activities was transferred to Asan Medical Center in Seoul, Republic of Korea with HFRS; his symptoms included high fever and generalized myalgia. The rapid diagnostic test performed immediately after his transfer detected HTNV-specific antibodies, and the patient was treated accordingly. However, two consecutive IFAs performed at ten-day intervals showed no HTNV-specific immunoglobulin (Ig) G. During continuous supportive care, next-generation sequencing successfully identified viral genomic sequences in the patient’s serum, which were SEOV and not HTNV. Phylogenetic analysis grouped the L, M, and S genes of this SEOV strain together with those of rat-or human-isolated Korean strains reported previously. Given global outbreaks and public health threats of zoonotic hantavi-ruses, a causative pathogen of hantavirus HFRS should be identified correctly at the time of diagnosis and by point-of-care testing.

Original languageEnglish
Article numbere0009168
Pages (from-to)1-8
Number of pages8
JournalPLoS Neglected Tropical Diseases
Issue number2
Publication statusPublished - 2021 Feb

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Human infection with seoul orthohantavirus in Korea, 2019'. Together they form a unique fingerprint.

Cite this