Human papillomavirus is more frequently detected in the pelvic than non-pelvic area in patients with squamous cell carcinoma in situ (Bowen’s disease)

Yoo Sang Baek, Jiehyun Jeon, Aeree Kim, Hae Jun Song, Chungyeul Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The detection rate of human papillomavirus (HPV) in Bowen’s disease (BD) varies greatly. Objectives: To detect HPV DNA in BD samples using next-generation sequencing (NGS) and compare HPV detection rates between pelvic and non-pelvic BD. Materials and Methods: We evaluated 99 patients with BD in our institution. DNA was extracted from formalin-fixed and paraffin embedded (FFPE) tissue blocks. The presence of HPV DNA material was detected using special kit-based NGS technology. Clinical characteristics and HPV detection rates were then compared between pelvic and non-pelvic BD samples. Results: HPV was detected in 26 (26.3%) BD samples. A total of 10 types of α-HPV was detected: HPV 16, 53, 31, 58, 66, 26, 27, 57, 45, and 72. The most common HPV type was 16 (12.1%). Only two types (27 and 57) were frequently classified as cutaneous type, and the rest were mucosal types. The HPV detection rate was significantly higher in pelvic BD (45.2%) compared to non-pelvic BD (17.6%). Conclusion: The present study suggests that sexually transmitted mucosal α-HPV plays a significant role in the pathogenesis of BD, especially in the pelvic region.

Original languageEnglish
Pages (from-to)111-118
Number of pages8
JournalEuropean Journal of Dermatology
Volume30
Issue number2
DOIs
Publication statusPublished - 2020 Mar 1

Keywords

  • Bowen’s disease
  • Human papillomavirus
  • Next-generation sequencing
  • Squamous cell carcinoma in situ
  • α-human papillomavirus

ASJC Scopus subject areas

  • Dermatology

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