Human T‐cell lymphotropic virus type I in Iranian‐born Mashhadi Jews: Genetic and phylogenetic evidence for common source of infection

V. R. Nerurkar, K. J. Song, R. R. Melland, R. Yanagihara, A. Achiron, E. Melamed, B. Shohat, O. Pinhas‐Hamiel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

High prevalence of human T‐cell lymphotropic virus type I (HTLV‐I) infection and disease has been identified among Iranian‐born Mashhadi Jews, an ethnically segregated, highly inbred population. To determine the origin and genetic diversity of HTLV‐I in this group, 1,039 bp spanning selected regions of the HTLV‐I gag, pol, env and pX genes were enzymatically amplified and sequenced directly from DMA of five Mashhadi Jews (three with spastic myelopathy and two asymptomatic carriers). Alignment and comparison of these sequences with cosmopolitan and Australo‐Melanesian topotypes of HTLV‐I indicated that the HTLV‐I strains from Mashhadi Jews, which were ⩾99.9% identical among themselves, exhibited considerable sequence similarity (⩾99%) to HTLV‐I strains from southern India, suggesting a common source of infection. Phylogenetic analysis, using the maximum parsimony method, was consistent with a single‐source introduction of HTLV‐I into the Mashhadi Jewish community. © 1995 Wiley‐Liss, Inc.

Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalJournal of Medical Virology
Volume45
Issue number4
DOIs
Publication statusPublished - 1995 Apr

Keywords

  • myelopathy
  • phylog‐eny
  • poly‐merase chain reaction
  • retrovirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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