Human T‐cell lymphotropic virus type I in Iranian‐born Mashhadi Jews: Genetic and phylogenetic evidence for common source of infection

V. R. Nerurkar, K. J. Song, R. R. Melland, R. Yanagihara, A. Achiron, E. Melamed, B. Shohat, O. Pinhas‐Hamiel

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    High prevalence of human T‐cell lymphotropic virus type I (HTLV‐I) infection and disease has been identified among Iranian‐born Mashhadi Jews, an ethnically segregated, highly inbred population. To determine the origin and genetic diversity of HTLV‐I in this group, 1,039 bp spanning selected regions of the HTLV‐I gag, pol, env and pX genes were enzymatically amplified and sequenced directly from DMA of five Mashhadi Jews (three with spastic myelopathy and two asymptomatic carriers). Alignment and comparison of these sequences with cosmopolitan and Australo‐Melanesian topotypes of HTLV‐I indicated that the HTLV‐I strains from Mashhadi Jews, which were ⩾99.9% identical among themselves, exhibited considerable sequence similarity (⩾99%) to HTLV‐I strains from southern India, suggesting a common source of infection. Phylogenetic analysis, using the maximum parsimony method, was consistent with a single‐source introduction of HTLV‐I into the Mashhadi Jewish community. © 1995 Wiley‐Liss, Inc.

    Original languageEnglish
    Pages (from-to)361-366
    Number of pages6
    JournalJournal of Medical Virology
    Volume45
    Issue number4
    DOIs
    Publication statusPublished - 1995 Apr

    Keywords

    • myelopathy
    • phylog‐eny
    • poly‐merase chain reaction
    • retrovirus

    ASJC Scopus subject areas

    • Virology
    • Infectious Diseases

    Fingerprint

    Dive into the research topics of 'Human T‐cell lymphotropic virus type I in Iranian‐born Mashhadi Jews: Genetic and phylogenetic evidence for common source of infection'. Together they form a unique fingerprint.

    Cite this