Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis

Hee-Jin Cheong, Joon-Young Song, Jeong Won Park, Jong Eun Yeon, Kwan Soo Byun, Chang Hong Lee, Hyun Il Cho, Tai Gyu Kim, Woo Joo Kim

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

Original languageEnglish
Pages (from-to)2417-2422
Number of pages6
JournalVaccine
Volume24
Issue number13
DOIs
Publication statusPublished - 2006 Mar 20

    Fingerprint

Keywords

  • Advanced cirrhosis
  • HI antibody
  • IFN-γ
  • Influenza vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this