Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis

Hee Jin Cheong; Joon Young Song; Jeong Won Park; Jong Eun Yeon; Kwan Soo Byun; Chang Hong Lee; Hyun Il Cho; Tai Gyu Kim; Woo Joo Kim

doi:10.1016/j.vaccine.2005.11.064

Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis

Hee Jin Cheong, Joon Young Song, Jeong Won Park, Jong Eun Yeon, Kwan Soo Byun, Chang Hong Lee, Hyun Il Cho, Tai Gyu Kim, Woo Joo Kim

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

Original language	English
Pages (from-to)	2417-2422
Number of pages	6
Journal	Vaccine
Volume	24
Issue number	13
DOIs	https://doi.org/10.1016/j.vaccine.2005.11.064
Publication status	Published - 2006 Mar 20

Keywords

Advanced cirrhosis
HI antibody
IFN-γ
Influenza vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2005.11.064

Cite this

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title = "Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis",

abstract = "Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.",

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author = "Cheong, {Hee Jin} and Song, {Joon Young} and Park, {Jeong Won} and Yeon, {Jong Eun} and Byun, {Kwan Soo} and Lee, {Chang Hong} and Cho, {Hyun Il} and Kim, {Tai Gyu} and Kim, {Woo Joo}",

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AU - Cheong, Hee Jin

AU - Song, Joon Young

AU - Park, Jeong Won

AU - Yeon, Jong Eun

AU - Byun, Kwan Soo

AU - Lee, Chang Hong

AU - Cho, Hyun Il

AU - Kim, Tai Gyu

AU - Kim, Woo Joo

PY - 2006/3/20

Y1 - 2006/3/20

N2 - Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

AB - Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

KW - Advanced cirrhosis

KW - HI antibody

KW - IFN-γ

KW - Influenza vaccine

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Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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