Humoral and cellular immune responses to influenza vaccine in patients with advanced cirrhosis

Hee Jin Cheong, Joon Young Song, Jeong Won Park, Jong Eun Yeon, Kwan Soo Byun, Chang Hong Lee, Hyun Il Cho, Tai Gyu Kim, Woo Joo Kim

    Research output: Contribution to journalArticlepeer-review

    38 Citations (Scopus)

    Abstract

    Influenza vaccine has been shown to successfully reduce influenza- and pneumonia-associated hospitalizations and deaths. Yet in liver cirrhosis, influenza vaccines have received little attention in determining the potential benefits. Thus, we undertook this study to evaluate the humoral and cellular immune responses to vaccination against influenza in patients with advanced cirrhosis. We measured interferon (IFN)-γ secretion response and hemagglutinin inhibition (HI) of antibody titer from pre- and post-vaccination blood samples in 80 cirrhotic patients (Child-Pugh class B or C) and 80 healthy, age-matched subjects. Although the patients with advanced cirrhosis showed similar humoral immune response against influenza vaccination compared to the healthy controls, cell-mediated immunity showed different results according to the remnant liver function.

    Original languageEnglish
    Pages (from-to)2417-2422
    Number of pages6
    JournalVaccine
    Volume24
    Issue number13
    DOIs
    Publication statusPublished - 2006 Mar 20

    Keywords

    • Advanced cirrhosis
    • HI antibody
    • IFN-γ
    • Influenza vaccine

    ASJC Scopus subject areas

    • Molecular Medicine
    • Immunology and Microbiology(all)
    • veterinary(all)
    • Public Health, Environmental and Occupational Health
    • Infectious Diseases

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