Abstract
Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.
| Original language | English |
|---|---|
| Pages (from-to) | 1569-1572 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2011 Feb 11 |
Keywords
- ferritin
- fluorescent probes
- imaging agents
- metalloenzymes
- nanoparticles
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Lin, X., Xie, J., Zhu, L., Lee, S., Niu, G., Ma, Y., Kim, K., & Chen, X. (2011). Hybrid ferritin nanoparticles as activatable probes for tumor imaging. Angewandte Chemie - International Edition, 50(7), 1569-1572. https://doi.org/10.1002/anie.201006757