Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin; Jin Xie; Lei Zhu; Seulki Lee; Gang Niu; Ying Ma; Kwangmeyung Kim; Xiaoyuan Chen

doi:10.1002/anie.201006757

Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Xin Lin, Jin Xie, Lei Zhu, Seulki Lee, Gang Niu, Ying Ma, Kwangmeyung Kim, Xiaoyuan Chen

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

Rattling the cage: Protein cages are used as a scaffold to build protease-activatable probes. The self-assembly of ferritin cages generates hybrid proteins with matrix metalloproteinase (MMP)-specific activation (see picture). The formula with the highest activation efficiency is validated as a tumor-specific probe in a xenograft mouse model.

Original language	English
Pages (from-to)	1569-1572
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	7
DOIs	https://doi.org/10.1002/anie.201006757
Publication status	Published - 2011 Feb 11
Externally published	Yes

Keywords

ferritin
fluorescent probes
imaging agents
metalloenzymes
nanoparticles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201006757

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AU - Zhu, Lei

AU - Lee, Seulki

AU - Niu, Gang

AU - Ma, Ying

AU - Kim, Kwangmeyung

AU - Chen, Xiaoyuan

PY - 2011/2/11

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KW - fluorescent probes

KW - imaging agents

KW - metalloenzymes

KW - nanoparticles

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Hybrid ferritin nanoparticles as activatable probes for tumor imaging

Abstract

Keywords

ASJC Scopus subject areas

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