Hydrodynamic micro-encapsulation of aqueous fluids and cells via 'on the fly' photopolymerization

Hyun Jik Oh, So Hyun Kim, Ju Yeoul Baek, Gi Hun Seong, Sang Hoon Lee

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

We report a new technique that, in contrast to conventional methods, uses a microfluidic platform for the fabrication of polymeric microcapsules that can contain sensitive biological materials. This encapsulation process is carried out through the use of hydrodynamic phenomena (e.g., multiphase laminar flow), and 'on the fly' photopolymerization. Our method allows for the generation of microcapsules whose size can be controlled by a regulation of flow rates, and the polymerized capsule can protect fragile materials, such as cells, DNA and enzymes from harsh environments. The proposed approach is extended to the fabrication of a microcontainer that can handle small volumes of liquid. The flexibility of the method across different materials and scales is a key advantage over many existing methods.

Original languageEnglish
Pages (from-to)285-291
Number of pages7
JournalJournal of Micromechanics and Microengineering
Volume16
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Instrumentation
  • Materials Science(all)
  • Mechanics of Materials
  • Computational Mechanics

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