Hydrogen peroxide induces vascular permeability via regulation of vascular endothelial growth factor

Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Hee Sun Park, Kyung Hoon Min, Min Hee Lee, Sun Mi Jin, Gong Yong Jin, Wan Hee Yoo, Yong Chul Lee

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Oxidative stress plays critical roles in initiation and/or worsening of respiratory disease process. Although reactive oxygen species (ROS) are shown to cause vascular leakage, the mechanisms by which ROS induce an increase in vascular permeability are not clearly understood. In this study, we have used a murine model to evaluate the effect of hydrogen peroxide (H2O 2) to examine roles of ROS and the molecular mechanism in vascular permeability. The results have revealed that ROS levels, vascular endothelial growth factor (VEGF) expression, hypoxia-inducible factor-1α protein level, airway hyperresponsiveness, and vascular permeability are increased after inhalation of H2O2. Administration of antioxidants markedly reduced plasma extravasation and VEGF levels in lungs treated with H2O2. These results indicate that ROS may modulate vascular permeability via upregulation of VEGF expression.

Original languageEnglish
Pages (from-to)190-197
Number of pages8
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume35
Issue number2
DOIs
Publication statusPublished - 2006 Aug

Keywords

  • Airway
  • Animal model
  • Hydrogen peroxide
  • Reactive oxygen species
  • Vascular endothelial growth factor
  • Vascular permeability

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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