Hydroquinone, a major component in cigarette smoke, reduces IFN-γ production in antigen-primed lymphocytes

Jin Myung Choi, Young Chang Cho, Won Jea Cho, Tae Sung Kim, Bok Yun Kang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Exposure to cigarette smoke is known to suppress immune responses and to increase the incidence and severity of respiratory infections. In this study, we determined the effect of hydroquinone (HQ), which is found at high concentrations in cigarette smoke, on interferon-gamma (IFN-γ) production by lymphocytes. HQ significantly inhibited IFN-γ secretion by keyhole limpet hemocyanin-primed lymphocytes in a dose-dependent manner. In addition, HQ inhibited IFN-γ secretion in effector CD4+ T cells and Th1-differentiated CD4+ T cells. The mRNA expression of IFN-γ and the IFN-γ gene promoter activity were inhibited by HQ. These results suggest that the inhibitory effect of HQ on IFN-γ secretion may occur at the transcriptional level. Furthermore, the effects of HQ on transcription factors were investigated. HQ inhibited the transcriptional activity of activator protein-1 and nuclear factor-κB, which are known to be involved in IFN-γ transcriptional activation. These findings provide evidence that HQ might suppress immune responses by reducing the production of IFN-γ and may explain the susceptibility to microbial infections caused by cigarette smoking.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalArchives of Pharmacal Research
Volume31
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

Fingerprint

Lymphocytes
Smoke
Tobacco Products
Interferon-gamma
Antigens
T-cells
T-Lymphocytes
hydroquinone
Transcription Factor AP-1
Respiratory Tract Infections
Transcriptional Activation
Transcription Factors
Genes
Smoking
Chemical activation
Messenger RNA
Incidence

Keywords

  • AP-1
  • Hydroquinone
  • IFN-γ
  • NF-κB
  • T cell

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Hydroquinone, a major component in cigarette smoke, reduces IFN-γ production in antigen-primed lymphocytes. / Choi, Jin Myung; Cho, Young Chang; Cho, Won Jea; Kim, Tae Sung; Kang, Bok Yun.

In: Archives of Pharmacal Research, Vol. 31, No. 3, 01.03.2008, p. 337-341.

Research output: Contribution to journalArticle

Choi, Jin Myung ; Cho, Young Chang ; Cho, Won Jea ; Kim, Tae Sung ; Kang, Bok Yun. / Hydroquinone, a major component in cigarette smoke, reduces IFN-γ production in antigen-primed lymphocytes. In: Archives of Pharmacal Research. 2008 ; Vol. 31, No. 3. pp. 337-341.
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