Abstract
Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.
| Original language | English |
|---|---|
| Pages (from-to) | 517-521 |
| Number of pages | 5 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2006 Jun 1 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biophysics
- Chemical Engineering(all)
- Bioengineering
Cite this
Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores. / Bae, Chang J.; Kim, Hae W.; Koh, Young-Hag; Kim, Hyoun E.
In: Journal of Materials Science: Materials in Medicine, Vol. 17, No. 6, 01.06.2006, p. 517-521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores
AU - Bae, Chang J.
AU - Kim, Hae W.
AU - Koh, Young-Hag
AU - Kim, Hyoun E.
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.
AB - Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.
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UR - http://www.scopus.com/inward/citedby.url?scp=33646577169&partnerID=8YFLogxK
U2 - 10.1007/s10856-006-8934-2
DO - 10.1007/s10856-006-8934-2
M3 - Article
C2 - 16691349
AN - SCOPUS:33646577169
VL - 17
SP - 517
EP - 521
JO - Journal of Materials Science: Materials in Electronics
JF - Journal of Materials Science: Materials in Electronics
SN - 0957-4522
IS - 6
ER -