Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

Chang Jun Bae, Hae Won Kim, Young Hag Koh, Hyoun Ee Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalJournal of Materials Science: Materials in Medicine
Volume17
Issue number6
DOIs
Publication statusPublished - 2006 Jun

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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