Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

Chang Jun Bae; Hae Won Kim; Young Hag Koh; Hyoun Ee Kim

doi:10.1007/s10856-006-8934-2

Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

Chang Jun Bae, Hae Won Kim, Young Hag Koh, Hyoun Ee Kim

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.

Original language	English
Pages (from-to)	517-521
Number of pages	5
Journal	Journal of Materials Science: Materials in Medicine
Volume	17
Issue number	6
DOIs	https://doi.org/10.1007/s10856-006-8934-2
Publication status	Published - 2006 Jun
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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10.1007/s10856-006-8934-2

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title = "Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores",

abstract = "Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.",

author = "Bae, {Chang Jun} and Kim, {Hae Won} and Koh, {Young Hag} and Kim, {Hyoun Ee}",

note = "Funding Information: Acknowledgments This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02–PJ3–PG6–EV11–0002).",

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doi = "10.1007/s10856-006-8934-2",

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AU - Bae, Chang Jun

AU - Kim, Hae Won

AU - Koh, Young Hag

AU - Kim, Hyoun Ee

N1 - Funding Information: Acknowledgments This work was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (02–PJ3–PG6–EV11–0002).

PY - 2006/6

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N2 - Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.

AB - Hydroxyapatite (HA) macrochanneled porous scaffolds, with a controlled pore structure, were fabricated via a combination of the extrusion and lamination processes. The scaffold was architectured by aligning and laminating the extruded HA and carbon filaments. The macrochannel pores were formed by removing the carbon filaments after thermal treatments (binder removal and sintering). The porosity of the scaffolds was varied between 48 and 73% with a controlled pore size of ∼450 μm, by adjusting the fractions of HA and carbon filaments. As the porosity was increased from 48 to 73%, the compressive strength decreased from 11.5 to 3.2 MPa. However, the osteoblast-like cell responses on the scaffold, such as the proliferation rate and alkaline phosphatase (ALP) activity, were significantly enhanced as the porosity was increased.

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Hydroxyapatite (HA) bone scaffolds with controlled macrochannel pores

Abstract

ASJC Scopus subject areas

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