Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera

A. Tefferi, M. A. Elliott, P. C. Kao, Soo-Young Yoon, I. El-Hemaidi, T. C. Pearson

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two prospectively studied patients with polycythemia vera (PV) whose platelet counts showed marked periodic fluctuation during treatment with hydroxyurea (HU) are reported. Cycle lengths in both were approximately 28 to 30 days. In one patient, the cyclic process was no longer evident when treatment with HU was with-held, and it reappeared on treatment rechallenge. Circulating thrombopoietin (TPO) levels fluctuated out of phase with the platelet count despite markedly reduced TPO-receptor (c-Mpl) expression in bone marrow megakaryocytes. These observations suggest that the cyclic phenomenon may be related to both a transient state of HU-induced depletion of megakaryocytes and a concentration-dependent mitigation by TPO of the HU effect on megakaryocytes and their precursors. It is conceivable that the affected patients harbor a megakaryocyte progenitor pool whose apoptotic activity is differently modulated by either HU or high concentrations of TPO. (C) 2000 by The American Society of Hematology.

Original languageEnglish
Pages (from-to)1582-1584
Number of pages3
JournalBlood
Volume96
Issue number4
Publication statusPublished - 2000 Aug 15
Externally publishedYes

Fingerprint

Polycythemia Vera
Hydroxyurea
Platelets
Platelet Count
Thrombopoietin
Megakaryocytes
Thrombopoietin Receptors
Megakaryocyte Progenitor Cells
Ports and harbors
Bone
Therapeutics
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

Tefferi, A., Elliott, M. A., Kao, P. C., Yoon, S-Y., El-Hemaidi, I., & Pearson, T. C. (2000). Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. Blood, 96(4), 1582-1584.

Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. / Tefferi, A.; Elliott, M. A.; Kao, P. C.; Yoon, Soo-Young; El-Hemaidi, I.; Pearson, T. C.

In: Blood, Vol. 96, No. 4, 15.08.2000, p. 1582-1584.

Research output: Contribution to journalArticle

Tefferi, A, Elliott, MA, Kao, PC, Yoon, S-Y, El-Hemaidi, I & Pearson, TC 2000, 'Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera', Blood, vol. 96, no. 4, pp. 1582-1584.
Tefferi A, Elliott MA, Kao PC, Yoon S-Y, El-Hemaidi I, Pearson TC. Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. Blood. 2000 Aug 15;96(4):1582-1584.
Tefferi, A. ; Elliott, M. A. ; Kao, P. C. ; Yoon, Soo-Young ; El-Hemaidi, I. ; Pearson, T. C. / Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera. In: Blood. 2000 ; Vol. 96, No. 4. pp. 1582-1584.
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