Hyperglycemia reduces efficiency of brain networks in subjects with type 2 diabetes

Dae Jin Kim, Ji Hee Yu, Mi Seon Shin, Yong Wook Shin, Min Seon Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Previous research has shown that the brain is an important target of diabetic complications. Since brain regions are interconnected to form a large-scale neural network, we investigated whether severe hyperglycemia affects the topology of the brain network in people with type 2 diabetes. Twenty middle-aged (average age: 54 years) individuals with poorly controlled diabetes (HbA1c: 8.9-14.6%, 74-136 mmol/mol) and 20 age-, sex-, and education- matched healthy volunteers were recruited. Graph theoretic network analysis was performed with axonal fiber tractography and tract-based spatial statistics (TBSS) using diffusion tensor imaging. Associations between the blood glucose level and white matter network characteristics were investigated. Individuals with diabetes had lower white matter network efficiency (P<0.001) and longer white matter path length (P<0.05) compared to healthy individuals. Higher HbA1c was associated with lower network efficiency (r = -0.53, P = 0.001) and longer network path length (r = 0.40, P<0.05). A disruption in local microstructural integrity was found in the multiple white matter regions and associated with higher HbA1c and fasting plasma glucose levels (corrected P<0.05). Poorer glycemic control is associated with lower efficiency and longer connection paths of the global brain network in individuals with diabetes. Chronic hyperglycemia in people with diabetes may disrupt the brain's topological integration, and lead to mental slowing and cognitive impairment.

Original languageEnglish
Article number0157268
JournalPloS one
Volume11
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

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hyperglycemia
Medical problems
noninsulin-dependent diabetes mellitus
Hyperglycemia
Type 2 Diabetes Mellitus
Brain
glycohemoglobin
diabetes
brain
middle-aged adults
Diffusion tensor imaging
glycemic control
Diffusion Tensor Imaging
Sex Education
Diabetes Complications
Electric network analysis
topology
neural networks
blood glucose
volunteers

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Hyperglycemia reduces efficiency of brain networks in subjects with type 2 diabetes. / Kim, Dae Jin; Yu, Ji Hee; Shin, Mi Seon; Shin, Yong Wook; Kim, Min Seon.

In: PloS one, Vol. 11, No. 6, 0157268, 01.06.2016.

Research output: Contribution to journalArticle

Kim, Dae Jin ; Yu, Ji Hee ; Shin, Mi Seon ; Shin, Yong Wook ; Kim, Min Seon. / Hyperglycemia reduces efficiency of brain networks in subjects with type 2 diabetes. In: PloS one. 2016 ; Vol. 11, No. 6.
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