Hyperhomocysteinemia due to levodopa treatment as a risk factor for osteoporosis in patients with parkinson's disease

Seung Hun Lee, Mi Jung Kim, Beom Jun Kim, Sung Reul Kim, Sail Chun, Hong Kyu Kim, Jin Sook Ryu, Ghi Su Kim, Myoung Chong Lee, Sun Ju Chung, Jung Min Koh

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Parkinson's disease (PD) patients have been reported to have lower bone mineral density (BMD) and higher fracture risk than individuals without PD. We assessed the association between hyperhomocysteinemia due to levodopa intake and BMD in PD patients. We measured serum homocysteine (Hcy) concentrations and BMD in the proximal femur and lumbar spine of PD patients aged 55 years or older (n = 95) and three age-/gender-matched control subjects (n = 285). The prevalence of osteoporosis was higher in both men (2.5-fold) and women (1.7-fold) with PD than in controls, and adjusted odds ratios for osteoporosis were 3.57 (95% confidence interval [CI], 1.25-10.20) for men and 2.54 for women (95% CI, 1.31-4.93) with PD. Serum Hcy concentrations were significantly higher in PD patients (median = 13.0 μmol/l) than controls (median = 11.5 μmol/l) (P = 0.005). Serum Hcy concentrations were independently associated with BMD values at all proximal femur sites in all subjects (P = 0.005 to 0.012). In PD patients, higher serum Hcy concentrations were independently associated with higher fracture risk (P = 0.029). PD patients taking higher doses of levodopa had significantly higher serum Hcy concentrations (P = 0.013), and greater levodopa intake was associated with lower BMD values in some areas (P = 0.008 to 0.029). In conclusion, these findings indicate that hyperhomocysteinemia due to levodopa intake may be one additional risk factor for osteoporosis and fracture in PD patients. Reducing Hcy may be a therapeutic modality for treating osteoporosis in PD patients taking levodopa.

Original languageEnglish
Pages (from-to)132-141
Number of pages10
JournalCalcified Tissue International
Volume86
Issue number2
DOIs
Publication statusPublished - 2010 Feb
Externally publishedYes

Keywords

  • Homocysteine
  • Levodopa
  • Osteoporosis
  • Parkinson's disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Fingerprint Dive into the research topics of 'Hyperhomocysteinemia due to levodopa treatment as a risk factor for osteoporosis in patients with parkinson's disease'. Together they form a unique fingerprint.

Cite this