Hypertension and vascular aging

Chang Gyu Park

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)

    Abstract

    Hypertension syndrome is a complex set of hemodynamic maladaptations that include stiff central arteries with pressure amplification, arteriolar constriction, microcirculatory rarefaction, metabolic abnormalities, cardiac hypertrophy and increased blood pressure variability. Cardiovascular aging in hypertension is accompanied by isolated systolic hypertension and an increased pulse pressure due to the increased central arterial stiffness, and patients with this malady have higher cardiovascular morbidity and mortality rates. Systolic hypertension causes endothelial dysfunction and atherosclerosis/ arteriosclerosis, so that the aortic compliance is reduced and the small resistance arteries are constricted with inward eutrophic remodeling. Central arterial stiffness increases the SBP variability and also the blunt aortocarotid baroreflex, which can cause orthostatic hypotension.

    Original languageEnglish
    Pages (from-to)477-481
    Number of pages5
    JournalKorean Circulation Journal
    Volume36
    Issue number7
    DOIs
    Publication statusPublished - 2006 Jul

    Keywords

    • Aging
    • Arterial stiffness
    • Atherosclerosis
    • Hypertension

    ASJC Scopus subject areas

    • Internal Medicine
    • Cardiology and Cardiovascular Medicine

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