Hyperthermia with magnetic nanowires for inactivating living cells

D. S. Choi; J. Park; S. Kim; D. H. Gracias; M. K. Cho; Y. K. Kim; A. Fung; S. E. Lee; Y. Chen; S. Khanal; S. Baral; J. H. Kim

doi:10.1166/jnn.2008.273

Hyperthermia with magnetic nanowires for inactivating living cells

D. S. Choi, J. Park, S. Kim, D. H. Gracias, M. K. Cho, Y. K. Kim, A. Fung, S. E. Lee, Y. Chen, S. Khanal, S. Baral, J. H. Kim

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.

Original language	English
Pages (from-to)	2323-2327
Number of pages	5
Journal	Journal of Nanoscience and Nanotechnology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1166/jnn.2008.273
Publication status	Published - 2008 May

Keywords

Hyperthermia
Nanowire
RF heating
Treatment of cancer

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Biomedical Engineering
Materials Science(all)
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1166/jnn.2008.273

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title = "Hyperthermia with magnetic nanowires for inactivating living cells",

abstract = "We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.",

keywords = "Hyperthermia, Nanowire, RF heating, Treatment of cancer",

author = "Choi, {D. S.} and J. Park and S. Kim and Gracias, {D. H.} and Cho, {M. K.} and Kim, {Y. K.} and A. Fung and Lee, {S. E.} and Y. Chen and S. Khanal and S. Baral and Kim, {J. H.}",

year = "2008",

month = may,

doi = "10.1166/jnn.2008.273",

language = "English",

volume = "8",

pages = "2323--2327",

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AU - Choi, D. S.

AU - Park, J.

AU - Kim, S.

AU - Gracias, D. H.

AU - Cho, M. K.

AU - Kim, Y. K.

AU - Fung, A.

AU - Lee, S. E.

AU - Chen, Y.

AU - Khanal, S.

AU - Baral, S.

AU - Kim, J. H.

PY - 2008/5

Y1 - 2008/5

N2 - We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.

AB - We describe a method to induce hyperthermia in cells, in-vitro, by remotely heating Ni nanowires (NWs) with radio frequency (RF) electromagnetic fields. Ni NWs were internalized by human embryonic kidney cells (HEK-293). Only cells proximal to NWs or with internalized NWs changed shape on exposure to RF fields indicative of cell death. The cell death occurs as a result of hyperthermia, since the RF field remotely heats the NWs as a result of magnetic hysteresis. This is the first demonstration of hyperthermia induced by NWs; since the NWs have anisotropic and strong magnetic moments, our experiments suggest the possibility of performing hyperthermia at lower field strengths in order to minimize damage to untargeted cells in applications such as the treatment of cancer.

KW - Hyperthermia

KW - Nanowire

KW - RF heating

KW - Treatment of cancer

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SN - 1533-4880

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JO - Journal of Nanoscience and Nanotechnology

JF - Journal of Nanoscience and Nanotechnology

IS - 5

ER -

Hyperthermia with magnetic nanowires for inactivating living cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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