Hyperuricaemia and development of type 2 diabetes mellitus in Asian population

Byoung Geol Choi, Dae Jin Kim, Man Jong Baek, Yang gi Ryu, Suhng Wook Kim, Min Woo Lee, Ji Young Park, Yung Kyun Noh, Se Yeon Choi, Jae Kyeong Byun, Min Suk Shim, Ahmed Mashaly, Hu Li, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Jah Yeon Choi, Eun Jin Park, Sung Hun ParkSunki Lee, Jin Oh Na, Cheol Ung Choi, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Seung-Woon Rha

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Recently, meta-analysis studies reported that hyperuricaemia is associated with higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited data on the Asian population. The aim of this observational study is to estimate the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular events. This study is based on a single-centre, all-comers, and large retrospective cohort. Subjects that visited from January 2004 to February 2014 were enrolled using the electronic database of Korea University Guro Hospital. A total of 10 505 patients without a history of T2DM were analyzed for uric acid, fasting glucose and haemoglobin (Hb) A1c level. Inclusion criteria included both Hb A1c <5.7% and fasting glucose level <100 mg/dL without T2DM. Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dL in men, and ≥6.5 mg/dL in women. To adjust baseline confounders, a propensity score matching (PSM) analysis was performed. The impact of hyperuricaemia on the new-onset T2DM and cardiovascular events were compared with the non-hyperuricaemia during the 5-year clinical follow-up. After PSM, baseline characteristics of both groups were balanced. In a 5-year follow-up, the hyperuricaemia itself was a strong independent predictor of the incidence of new-onset T2DM (HR, 1.78; 95% CI, 1.12 to 2.8). Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Also, hyperuricaemia is substantially implicated in cardiovascular risks and the further long-term cardiovascular events in the crude population, but it is not an independent predictor of long-term cardiovascular mortality in the matched population.

Original languageEnglish
JournalClinical and Experimental Pharmacology and Physiology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Type 2 Diabetes Mellitus
Population
Uric Acid
Propensity Score
Insulin Resistance
Fasting
Hemoglobins
Glucose
Incidence
Korea
Observational Studies
Meta-Analysis
Databases
Mortality

Keywords

  • Diabetes mellitus
  • Hyperuricaemia
  • Risk factors
  • Uric acid

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Hyperuricaemia and development of type 2 diabetes mellitus in Asian population. / Choi, Byoung Geol; Kim, Dae Jin; Baek, Man Jong; Ryu, Yang gi; Kim, Suhng Wook; Lee, Min Woo; Park, Ji Young; Noh, Yung Kyun; Choi, Se Yeon; Byun, Jae Kyeong; Shim, Min Suk; Mashaly, Ahmed; Li, Hu; Park, Yoonjee; Jang, Won Young; Kim, Woohyeun; Kang, Jun Hyuk; Choi, Jah Yeon; Park, Eun Jin; Park, Sung Hun; Lee, Sunki; Na, Jin Oh; Choi, Cheol Ung; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Rha, Seung-Woon.

In: Clinical and Experimental Pharmacology and Physiology, 01.01.2018.

Research output: Contribution to journalArticle

Choi, BG, Kim, DJ, Baek, MJ, Ryu, YG, Kim, SW, Lee, MW, Park, JY, Noh, YK, Choi, SY, Byun, JK, Shim, MS, Mashaly, A, Li, H, Park, Y, Jang, WY, Kim, W, Kang, JH, Choi, JY, Park, EJ, Park, SH, Lee, S, Na, JO, Choi, CU, Kim, EJ, Park, CG, Seo, HS, Oh, DJ & Rha, S-W 2018, 'Hyperuricaemia and development of type 2 diabetes mellitus in Asian population', Clinical and Experimental Pharmacology and Physiology. https://doi.org/10.1111/1440-1681.12911
Choi, Byoung Geol ; Kim, Dae Jin ; Baek, Man Jong ; Ryu, Yang gi ; Kim, Suhng Wook ; Lee, Min Woo ; Park, Ji Young ; Noh, Yung Kyun ; Choi, Se Yeon ; Byun, Jae Kyeong ; Shim, Min Suk ; Mashaly, Ahmed ; Li, Hu ; Park, Yoonjee ; Jang, Won Young ; Kim, Woohyeun ; Kang, Jun Hyuk ; Choi, Jah Yeon ; Park, Eun Jin ; Park, Sung Hun ; Lee, Sunki ; Na, Jin Oh ; Choi, Cheol Ung ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo ; Rha, Seung-Woon. / Hyperuricaemia and development of type 2 diabetes mellitus in Asian population. In: Clinical and Experimental Pharmacology and Physiology. 2018.
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AU - Choi, Byoung Geol

AU - Kim, Dae Jin

AU - Baek, Man Jong

AU - Ryu, Yang gi

AU - Kim, Suhng Wook

AU - Lee, Min Woo

AU - Park, Ji Young

AU - Noh, Yung Kyun

AU - Choi, Se Yeon

AU - Byun, Jae Kyeong

AU - Shim, Min Suk

AU - Mashaly, Ahmed

AU - Li, Hu

AU - Park, Yoonjee

AU - Jang, Won Young

AU - Kim, Woohyeun

AU - Kang, Jun Hyuk

AU - Choi, Jah Yeon

AU - Park, Eun Jin

AU - Park, Sung Hun

AU - Lee, Sunki

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Rha, Seung-Woon

PY - 2018/1/1

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N2 - Recently, meta-analysis studies reported that hyperuricaemia is associated with higher incidence of type 2 diabetes mellitus (T2DM), however, there are limited data on the Asian population. The aim of this observational study is to estimate the long-term impact of hyperuricaemia on the new-onset T2DM and cardiovascular events. This study is based on a single-centre, all-comers, and large retrospective cohort. Subjects that visited from January 2004 to February 2014 were enrolled using the electronic database of Korea University Guro Hospital. A total of 10 505 patients without a history of T2DM were analyzed for uric acid, fasting glucose and haemoglobin (Hb) A1c level. Inclusion criteria included both Hb A1c <5.7% and fasting glucose level <100 mg/dL without T2DM. Hyperuricaemia was defined as a uric acid level ≥7.0 mg/dL in men, and ≥6.5 mg/dL in women. To adjust baseline confounders, a propensity score matching (PSM) analysis was performed. The impact of hyperuricaemia on the new-onset T2DM and cardiovascular events were compared with the non-hyperuricaemia during the 5-year clinical follow-up. After PSM, baseline characteristics of both groups were balanced. In a 5-year follow-up, the hyperuricaemia itself was a strong independent predictor of the incidence of new-onset T2DM (HR, 1.78; 95% CI, 1.12 to 2.8). Hyperuricaemia was a strong independent predictor of new-onset T2DM, which suggests a substantial implication for a correlation between uric acid concentration and insulin resistance (or insulin sensitivity). Also, hyperuricaemia is substantially implicated in cardiovascular risks and the further long-term cardiovascular events in the crude population, but it is not an independent predictor of long-term cardiovascular mortality in the matched population.

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