Hypocholesterol effect of Opuntia humifusa extract on high cholesterol diet-induced hypercholesterolemic rats

Eun Young Jung, Seong Ho Yeon, Hyung Joo Suh

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to investigate the hypocholesterol effects of Opuntia humifusa extract in hypercholesterolemic rats. Rats (8-week-old, male) were randomly divided into four groups (n=4) as follows: N-control, normal diet; H-control, hypercholesterolemic diet; OH-1, 2% O. humifusa extract-supplemented hypercholesterolemic diet; OH-2, 4% O. humifusa extract-supplemented hypercholesterolemic diet. After 4 weeks, we observed that hypercholesterolemia induced significant increases in serum lipids (total cholesterol and LDL-cholesterol), hepatic lipids (total cholesterol and triglyceride), and hepatic function parameters (ALT, alanine aminotransferase; AST, aspartate aminotransferase) (P<0.05). Treatment with O. humifusa extract for 2 weeks normalized these indexes up to the levels of normal rats. O. humifusa extract tended to increase fecal lipid (H-control: 142.74 mg/day vs. OH-1: 214.05 mg/day; OH-2: 200.95 mg/day, P<0.05) and bile acid (H-control: 37.07 μM/day vs. OH-1: 47.23 μM/day, OH-2: 47.93 μM/day, P<0.05) contents of hypercholesterolemic rats. We concluded that oral administration of O. humifusa extract effectively improved cholesterol metabolism in a hypercholesterolemic animal model induced by hypercholesterol diet.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalJournal of the Korean Society of Food Science and Nutrition
Volume43
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Opuntia humifusa
Opuntia
high fat diet
Cholesterol
Diet
rats
extracts
diet
Lipids
cholesterol
cholesterol metabolism
hypercholesterolemia
Liver
liver function
bile acids
lipids
Aspartate Aminotransferases
Hypercholesterolemia
Bile Acids and Salts
Alanine Transaminase

Keywords

  • Cholesterol
  • Hypercholesterolemia
  • LDL-cholesterol
  • Opuntia humifusa extract

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Food Science

Cite this

Hypocholesterol effect of Opuntia humifusa extract on high cholesterol diet-induced hypercholesterolemic rats. / Jung, Eun Young; Yeon, Seong Ho; Suh, Hyung Joo.

In: Journal of the Korean Society of Food Science and Nutrition, Vol. 43, No. 4, 2014, p. 485-490.

Research output: Contribution to journalArticle

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