Hypoglycemia and medical expenses in patients with type 2 diabetes mellitus: An analysis based on the korea national diabetes program cohort

Sang Youl Rhee, Soo Min Hong, Suk Chon, Kyu Jeung Ahn, Sung Hoon Kim, Sei-Hyun Baik, Yong Soo Park, Moon Suk Nam, Kwan Woo Lee, Jeong Taek Woo, Young Seol Kim

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Abstract

Background and Aims: Hypoglycemia is one of the most important adverse events in individuals with type 2 diabetes mellitus (T2DM). However, hypoglycemia-related events are usually overlooked and have been documented less in clinical practice. Materials and Methods: We evaluated the incidence, clinical characteristics, and medical expenses of hypoglycemia related events in T2DM patients based on the Korea National Diabetes Program (KNDP), which is the largest multi-center, prospective cohort in Korea (n = 4,350). For accurate outcomes, the KNDP data were merged with claims data from the Health Insurance Review and Assessment Service (HIRA) of Korea. Results: During a median follow-up period of 3.23 years (95% CI: 3.14, 3.19), 88 subjects (2.02%) were newly diagnosed with hypoglycemia, and the incidence of hypoglycemia was 6.44 cases per 1,000 person-years (PY). Individuals with hypoglycemia were significantly older (59.7±10.7 vs. 53.3±10.4 years, p < 0.001), had more hospital visits (121.94±126.88 days/ PY, p < 0.001), had a longer hospital stays (16.13±29.21 days/PY, p < 0.001), and incurred greater medical costs ($2,447.56±4,056.38 vs. $1,336.37±3,403.39 /PY, p < 0.001) than subjects without hypoglycemia. Conclusion: Hypoglycemia-related events were infrequently identified among the medical records of T2DM subjects. However, they were associated significantly with poor clinical outcomes, and thus, hypoglycemia could have a substantial burden on the Korean national healthcare system.

Original languageEnglish
Article numbere0148630
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Rhee, S. Y., Hong, S. M., Chon, S., Ahn, K. J., Kim, S. H., Baik, S-H., Park, Y. S., Nam, M. S., Lee, K. W., Woo, J. T., & Kim, Y. S. (2016). Hypoglycemia and medical expenses in patients with type 2 diabetes mellitus: An analysis based on the korea national diabetes program cohort. PLoS One, 11(2), [e0148630]. https://doi.org/10.1371/journal.pone.0148630