Hypoglycemia is associated with dementia in elderly patients with type 2 diabetes mellitus: An analysis based on the Korea National Diabetes Program Cohort

Sang Ouk Chin, Sang Youl Rhee, Suk Chon, Sei Hyun Baik, Yongsoo Park, Moon Suk Nam, Kwan Woo Lee, Ki Hong Chun, Jeong taek Woo, Young Seol Kim

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Aim Although hypoglycemia is associated with cognitive dysfunction, including dementia, in patients with type 2 diabetes mellitus (DM), the data are equivocal. The purpose of this study was to investigate the association between hypoglycemia, dementia, and other cognitive dysfunctions. Methods This was a prospective observational study based upon the Korea National Diabetes Program (KNDP). Among the 4540 participants in the KNDP cohort, individuals aged ⩾60 years without any history of hypoglycemia or cognitive dysfunction (n = 1957) were included. Nationally representative data from the Health Insurance Review and Assessment Service of Korea claim database were used to obtain a more precise determination of patient outcome. Results During a mean follow-up period of 3.4 ± 0.9 years, 118 subjects experienced hypoglycemia-related events. The incidence of dementia and cognitive dysfunction was 7.5 cases per 1000 person-years (PY) and 0.61 cases per 1000 PY, respectively. In the subjects who experienced hypoglycemic events (relative to those who did not), the incidence of dementia was significantly higher (P = 0.0139), but the incidence of cognitive dysfunction was not (P = 0.1106). Hypoglycemic events were associated with dementia (HR, 2.689; 95% CI, 1.080–6.694, P = 0.0335) following multiple adjustments. There was also a significant linear trend toward an increased dementia risk commensurate with an increasing number of hypoglycemic events (P = 0.0286). Conclusions Hypoglycemia is significantly associated with the risk of dementia in Korean type 2 DM patients aged ⩾60 years.

    Original languageEnglish
    Pages (from-to)54-61
    Number of pages8
    JournalDiabetes Research and Clinical Practice
    Volume122
    DOIs
    Publication statusPublished - 2016 Dec 1

    Keywords

    • Dementia
    • Hypoglycemia
    • Type 2 diabetes

    ASJC Scopus subject areas

    • Internal Medicine
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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