Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice

Jong Ho Kim, Yaoyao Jia, Jung Gyu Lee, Bora Nam, Ji Hae Lee, Kwang Soon Shin, Byung Serk Hurh, Yong Ho Choi, Sung-Joon Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Meju, a naturally fermented soy block used to produce soy paste and soy sauce in Korea, is suggested to exhibit hypolipidemic and antiinflammatory activities; however, its mechanisms of action are elusive. Here, we report that the water-soluble fibers but not the amino acids and peptides from meju exhibited hypolipidemic activity in vivo. Feeding of fermented soybean fibers (FSF) from meju reduced plasma cholesterol, triglyceride, adipocyte size, and hepatic lipid accumulation in C57BL/6 J mice. FSF treatment reduced HMG-CoA reductase expression, whereas the expression of genes in the fatty acid uptake and subsequent beta-oxidation were significantly induced in the livers. Hepatic lipogenic genes, including Srebp1c and Lxrá, were unaltered. Feeding with the fermented soybean peptides and amino acids (FSPA) induced the expression of lipogenic genes, which may have canceled the induction of low-density lipoprotein receptor and Cyp7a1 gene expressions in FSPA livers. The plasma concentrations of C-reactive protein, TNF-&alpha, and interlukin-6 were significantly reduced in the FSF, FSPA, and meju groups compared with the control groups, suggesting that both of the fibers and peptides/amino acids from meju may be beneficial. These findings suggest that soluble fibers from meju are critical hypolipidemic components that regulate hepatic gene expressions and reduce proinflammatory cytokines in vivo.

Original languageEnglish
Pages (from-to)1335-1341
Number of pages7
JournalPhytotherapy Research
Volume28
Issue number9
DOIs
Publication statusPublished - 2014 Jan 1

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Soybeans
Amino Acids
Peptides
Liver
Gene Expression
Soy Foods
Hydroxymethylglutaryl CoA Reductases
LDL Receptors
Korea
Ointments
Adipocytes
C-Reactive Protein
Triglycerides
Anti-Inflammatory Agents
Fatty Acids
Cholesterol
Cytokines
Lipids
Control Groups
Water

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

Cite this

Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice. / Kim, Jong Ho; Jia, Yaoyao; Lee, Jung Gyu; Nam, Bora; Lee, Ji Hae; Shin, Kwang Soon; Hurh, Byung Serk; Choi, Yong Ho; Lee, Sung-Joon.

In: Phytotherapy Research, Vol. 28, No. 9, 01.01.2014, p. 1335-1341.

Research output: Contribution to journalArticle

Kim, JH, Jia, Y, Lee, JG, Nam, B, Lee, JH, Shin, KS, Hurh, BS, Choi, YH & Lee, S-J 2014, 'Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice', Phytotherapy Research, vol. 28, no. 9, pp. 1335-1341. https://doi.org/10.1002/ptr.5134
Kim, Jong Ho ; Jia, Yaoyao ; Lee, Jung Gyu ; Nam, Bora ; Lee, Ji Hae ; Shin, Kwang Soon ; Hurh, Byung Serk ; Choi, Yong Ho ; Lee, Sung-Joon. / Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice. In: Phytotherapy Research. 2014 ; Vol. 28, No. 9. pp. 1335-1341.
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