Abstract
Meju, a naturally fermented soy block used to produce soy paste and soy sauce in Korea, is suggested to exhibit hypolipidemic and antiinflammatory activities; however, its mechanisms of action are elusive. Here, we report that the water-soluble fibers but not the amino acids and peptides from meju exhibited hypolipidemic activity in vivo. Feeding of fermented soybean fibers (FSF) from meju reduced plasma cholesterol, triglyceride, adipocyte size, and hepatic lipid accumulation in C57BL/6 J mice. FSF treatment reduced HMG-CoA reductase expression, whereas the expression of genes in the fatty acid uptake and subsequent beta-oxidation were significantly induced in the livers. Hepatic lipogenic genes, including Srebp1c and Lxrá, were unaltered. Feeding with the fermented soybean peptides and amino acids (FSPA) induced the expression of lipogenic genes, which may have canceled the induction of low-density lipoprotein receptor and Cyp7a1 gene expressions in FSPA livers. The plasma concentrations of C-reactive protein, TNF-&alpha, and interlukin-6 were significantly reduced in the FSF, FSPA, and meju groups compared with the control groups, suggesting that both of the fibers and peptides/amino acids from meju may be beneficial. These findings suggest that soluble fibers from meju are critical hypolipidemic components that regulate hepatic gene expressions and reduce proinflammatory cytokines in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 1335-1341 |
| Number of pages | 7 |
| Journal | Phytotherapy Research |
| Volume | 28 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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ASJC Scopus subject areas
- Pharmacology
- Medicine(all)
Cite this
Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice. / Kim, Jong Ho; Jia, Yaoyao; Lee, Jung Gyu; Nam, Bora; Lee, Ji Hae; Shin, Kwang Soon; Hurh, Byung Serk; Choi, Yong Ho; Lee, Sung-Joon.
In: Phytotherapy Research, Vol. 28, No. 9, 01.01.2014, p. 1335-1341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypolipidemic and antiinflammation activities of fermented soybean fibers from meju in C57BL/6 J mice
AU - Kim, Jong Ho
AU - Jia, Yaoyao
AU - Lee, Jung Gyu
AU - Nam, Bora
AU - Lee, Ji Hae
AU - Shin, Kwang Soon
AU - Hurh, Byung Serk
AU - Choi, Yong Ho
AU - Lee, Sung-Joon
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Meju, a naturally fermented soy block used to produce soy paste and soy sauce in Korea, is suggested to exhibit hypolipidemic and antiinflammatory activities; however, its mechanisms of action are elusive. Here, we report that the water-soluble fibers but not the amino acids and peptides from meju exhibited hypolipidemic activity in vivo. Feeding of fermented soybean fibers (FSF) from meju reduced plasma cholesterol, triglyceride, adipocyte size, and hepatic lipid accumulation in C57BL/6 J mice. FSF treatment reduced HMG-CoA reductase expression, whereas the expression of genes in the fatty acid uptake and subsequent beta-oxidation were significantly induced in the livers. Hepatic lipogenic genes, including Srebp1c and Lxrá, were unaltered. Feeding with the fermented soybean peptides and amino acids (FSPA) induced the expression of lipogenic genes, which may have canceled the induction of low-density lipoprotein receptor and Cyp7a1 gene expressions in FSPA livers. The plasma concentrations of C-reactive protein, TNF-&alpha, and interlukin-6 were significantly reduced in the FSF, FSPA, and meju groups compared with the control groups, suggesting that both of the fibers and peptides/amino acids from meju may be beneficial. These findings suggest that soluble fibers from meju are critical hypolipidemic components that regulate hepatic gene expressions and reduce proinflammatory cytokines in vivo.
AB - Meju, a naturally fermented soy block used to produce soy paste and soy sauce in Korea, is suggested to exhibit hypolipidemic and antiinflammatory activities; however, its mechanisms of action are elusive. Here, we report that the water-soluble fibers but not the amino acids and peptides from meju exhibited hypolipidemic activity in vivo. Feeding of fermented soybean fibers (FSF) from meju reduced plasma cholesterol, triglyceride, adipocyte size, and hepatic lipid accumulation in C57BL/6 J mice. FSF treatment reduced HMG-CoA reductase expression, whereas the expression of genes in the fatty acid uptake and subsequent beta-oxidation were significantly induced in the livers. Hepatic lipogenic genes, including Srebp1c and Lxrá, were unaltered. Feeding with the fermented soybean peptides and amino acids (FSPA) induced the expression of lipogenic genes, which may have canceled the induction of low-density lipoprotein receptor and Cyp7a1 gene expressions in FSPA livers. The plasma concentrations of C-reactive protein, TNF-&alpha, and interlukin-6 were significantly reduced in the FSF, FSPA, and meju groups compared with the control groups, suggesting that both of the fibers and peptides/amino acids from meju may be beneficial. These findings suggest that soluble fibers from meju are critical hypolipidemic components that regulate hepatic gene expressions and reduce proinflammatory cytokines in vivo.
KW - Inflammation
KW - Lipid metabolism
KW - Meju
KW - Soybean fibers
UR - http://www.scopus.com/inward/record.url?scp=84907922758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907922758&partnerID=8YFLogxK
U2 - 10.1002/ptr.5134
DO - 10.1002/ptr.5134
M3 - Article
C2 - 24623672
AN - SCOPUS:84907922758
VL - 28
SP - 1335
EP - 1341
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 9
ER -