Hypothermia alleviates hypoxic ischemia-induced dopamine dysfunction and memory impairment in rats

Il Gyu Ko, Han Jin Cho, Sung Eun Kim, Ji Eun Kim, Yun Hee Sung, Bo Kyun Kim, Mal Soon Shin, Sehyung Cho, Youngmi Kim Pak, Chang Ju Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypoxic ischemia injury is a common cause of functional brain damage, resulting from a decrease in cerebral blood flow and oxygen supply to the brain. The main problems associated with hypoxic ischemia to the brain are memory impairment and dopamine dysfunction. Hypothermia has been suggested to ameliorate the neurological impairment induced by various brain insults. In this study, we investigated the effects of hypothermia on memory function and dopamine synthesis following hypoxic ischemia to the brain in rats. For this purpose, a step-down avoidance task, a radial eight-arm maze task, and immunohistochemistry for tyrosine hydroxylase (TH) and 5-bromo-2′-deoxyuridine (BrdU) were performed. The present results indicated that the hypoxic ischemia-induced disturbance of the animal's performances and spatial working memory was associated with a decrement in TH expression in the substantia nigra and striatum, and an increase in cell proliferation in the hippocampal dentate gyrus. Hypothermia treatment improved the animals' performance and spatial working memory by suppressing the decrement in TH expression in the substantia nigra and striatum and the increase in cell proliferation in the dentate gyrus. We suggest that hypothermia can be an efficient therapeutic modality to facilitate recovery following hypoxic ischemia injury to the brain, presumably by modulating the dopaminergic cell loss.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalAnimal Cells and Systems
Volume15
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Hypothermia
hypothermia
tyrosine 3-monooxygenase
ischemia
dopamine
Rats
Dopamine
Brain
Tyrosine 3-Monooxygenase
Ischemia
brain
Data storage equipment
rats
Dentate Gyrus
Substantia Nigra
Brain Ischemia
Short-Term Memory
animal performance
Cerebrovascular Circulation
Cell Proliferation

Keywords

  • cell proliferation
  • dopamine
  • hypothermia
  • hypoxic ischemia
  • memory

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Animal Science and Zoology

Cite this

Hypothermia alleviates hypoxic ischemia-induced dopamine dysfunction and memory impairment in rats. / Ko, Il Gyu; Cho, Han Jin; Kim, Sung Eun; Kim, Ji Eun; Sung, Yun Hee; Kim, Bo Kyun; Shin, Mal Soon; Cho, Sehyung; Pak, Youngmi Kim; Kim, Chang Ju.

In: Animal Cells and Systems, Vol. 15, No. 4, 01.12.2011, p. 279-286.

Research output: Contribution to journalArticle

Ko, IG, Cho, HJ, Kim, SE, Kim, JE, Sung, YH, Kim, BK, Shin, MS, Cho, S, Pak, YK & Kim, CJ 2011, 'Hypothermia alleviates hypoxic ischemia-induced dopamine dysfunction and memory impairment in rats', Animal Cells and Systems, vol. 15, no. 4, pp. 279-286. https://doi.org/10.1080/19768354.2011.607514
Ko, Il Gyu ; Cho, Han Jin ; Kim, Sung Eun ; Kim, Ji Eun ; Sung, Yun Hee ; Kim, Bo Kyun ; Shin, Mal Soon ; Cho, Sehyung ; Pak, Youngmi Kim ; Kim, Chang Ju. / Hypothermia alleviates hypoxic ischemia-induced dopamine dysfunction and memory impairment in rats. In: Animal Cells and Systems. 2011 ; Vol. 15, No. 4. pp. 279-286.
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