Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain

Richard C. Li, Seung Kwan Lee, Farzan Pouranfar, Kenneth R. Brittian, Heather B. Clair, Barry W. Row, Yang Wang, David Gozal

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O 2 ) or intermittent hypoxia (IH; 10% and 21% O 2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalBrain Research
Volume1096
Issue number1
DOIs
Publication statusPublished - 2006 Jun 22
Externally publishedYes

Fingerprint

Brain
Globins
Messenger RNA
neuroglobin
cytoglobin
Hypoxia
Rodentia
Proteins
Genes

Keywords

  • Brain
  • Cytoglobin
  • Hypoxia
  • Neuroglobin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Li, R. C., Lee, S. K., Pouranfar, F., Brittian, K. R., Clair, H. B., Row, B. W., ... Gozal, D. (2006). Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. Brain Research, 1096(1), 173-179. https://doi.org/10.1016/j.brainres.2006.04.063

Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. / Li, Richard C.; Lee, Seung Kwan; Pouranfar, Farzan; Brittian, Kenneth R.; Clair, Heather B.; Row, Barry W.; Wang, Yang; Gozal, David.

In: Brain Research, Vol. 1096, No. 1, 22.06.2006, p. 173-179.

Research output: Contribution to journalArticle

Li, RC, Lee, SK, Pouranfar, F, Brittian, KR, Clair, HB, Row, BW, Wang, Y & Gozal, D 2006, 'Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain', Brain Research, vol. 1096, no. 1, pp. 173-179. https://doi.org/10.1016/j.brainres.2006.04.063
Li, Richard C. ; Lee, Seung Kwan ; Pouranfar, Farzan ; Brittian, Kenneth R. ; Clair, Heather B. ; Row, Barry W. ; Wang, Yang ; Gozal, David. / Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain. In: Brain Research. 2006 ; Vol. 1096, No. 1. pp. 173-179.
@article{32e9f3024ed24c9f8d6c28a711a0fb8c,
title = "Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain",
abstract = "Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10{\%} O 2 ) or intermittent hypoxia (IH; 10{\%} and 21{\%} O 2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.",
keywords = "Brain, Cytoglobin, Hypoxia, Neuroglobin",
author = "Li, {Richard C.} and Lee, {Seung Kwan} and Farzan Pouranfar and Brittian, {Kenneth R.} and Clair, {Heather B.} and Row, {Barry W.} and Yang Wang and David Gozal",
year = "2006",
month = "6",
day = "22",
doi = "10.1016/j.brainres.2006.04.063",
language = "English",
volume = "1096",
pages = "173--179",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain

AU - Li, Richard C.

AU - Lee, Seung Kwan

AU - Pouranfar, Farzan

AU - Brittian, Kenneth R.

AU - Clair, Heather B.

AU - Row, Barry W.

AU - Wang, Yang

AU - Gozal, David

PY - 2006/6/22

Y1 - 2006/6/22

N2 - Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O 2 ) or intermittent hypoxia (IH; 10% and 21% O 2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

AB - Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O 2 ) or intermittent hypoxia (IH; 10% and 21% O 2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

KW - Brain

KW - Cytoglobin

KW - Hypoxia

KW - Neuroglobin

UR - http://www.scopus.com/inward/record.url?scp=33745264870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745264870&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2006.04.063

DO - 10.1016/j.brainres.2006.04.063

M3 - Article

C2 - 16750520

AN - SCOPUS:33745264870

VL - 1096

SP - 173

EP - 179

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -