Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain

Richard C. Li, Seung Kwan Lee, Farzan Pouranfar, Kenneth R. Brittian, Heather B. Clair, Barry W. Row, Yang Wang, David Gozal

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O2) or intermittent hypoxia (IH; 10% and 21% O2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalBrain Research
Volume1096
Issue number1
DOIs
Publication statusPublished - 2006 Jun 22
Externally publishedYes

Keywords

  • Brain
  • Cytoglobin
  • Hypoxia
  • Neuroglobin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain'. Together they form a unique fingerprint.

Cite this