Hypoxia-inducible factor-1 and nuclear factor-κB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

Cheng Zhu Wu, Seong Su Hong, Xing Fu Cai, Nguyen Tien Dat, Ji Xing Nan, Bang Yeon Hwang, Jung Joon Lee, Dongho Lee

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12′S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-κB inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-κB activation without significantly decreasing the viability of the AGS and HeLa cells, respectively.

Original languageEnglish
Pages (from-to)2619-2623
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number8
DOIs
Publication statusPublished - 2008 Apr 15

Keywords

  • Fabaceae
  • Hypoxia-inducible factor-1
  • Meroterpenoids
  • Nuclear factor-κB
  • Psoralea corylifolia

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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