Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus

Beom Seok Kim, Hyuncheol Oh, Sun Young Kim, Jeong Ah Park, Yeo Joon Yoon, Sang Kil Lee, Bo Yeon Kim, Jong Seog Ahn

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1 Citation (Scopus)

Abstract

During the study on the oleandomycin production, we purified a new oleandomycin derivative having a macrolactone of which biosynthesis does not follow the genetic architecture of the oleandomycin PKS. The molecular formula for the compound was suggested as C35H59NO11 on the basis of the analysis of NMR and HRMS data (m/z 670.4185, Δ-1.9 mmu, calcd for C35H60NO11). 13C NMR assignments and analysis of COSY, HMBC and HMQC data suggested that the compound differs from oleandomycin by formation of the olefinic functionality resulting from the dehydration of a hydroxy group in oleandomycin. The new oleandomycin derivative has antibacterial activities similar to those of oleandomycin agaisnt Enterococcus faecalis, Bacillus subtilis and Staphylococcus aureus.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalJournal of Antibiotics
Volume58
Issue number3
Publication statusPublished - 2005 Mar 1
Externally publishedYes

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Keywords

  • Dehydration of hydroxyl group
  • New oleandomycin derivative
  • Olefinic formation
  • Streptomyces antibioticus

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Kim, B. S., Oh, H., Kim, S. Y., Park, J. A., Yoon, Y. J., Lee, S. K., Kim, B. Y., & Ahn, J. S. (2005). Identification and antibacterial activity of a new oleandomycin derivative from streptomyces antibioticus. Journal of Antibiotics, 58(3), 196-201.