Identification and characterization of new microRNAs from pig

Jung Kim, Ik Sang Cho, Jae Sang Hong, Young K. Choi, Hyunggee Kim, Youngsik Lee

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small regulatory RNAs that direct the posttranscriptional repression of cognate messenger RNAs. Despite increasing evidence for diverse roles of miRNAs in biological processes, little is known about miRNAs in pig. We describe the first experimental identification of porcine miRNAs by sequence analysis of a cDNA library of small RNAs from porcine fibroblast cells. We identified 25 distinct porcine miRNAs, of which 19 are previously unreported, and define 14 new miRNA families in pig. Most of the cloned miRNAs are expressed ubiquitously in all porcine tissues examined, whereas some miRNAs are expressed preferentially in specific tissues. Our results enrich the porcine miRNA database and provide useful information for investigating biological functions of miRNAs in pig.

Original languageEnglish
Pages (from-to)570-580
Number of pages11
JournalMammalian Genome
Volume19
Issue number7-8
DOIs
Publication statusPublished - 2008 Aug 1

ASJC Scopus subject areas

  • Genetics

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