Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus

Na Young Park, Jeong Hyun Lee, Byung Cheol Lee, Tae Sung Kim, Sang Ho Choi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A wbpO gene encoding a putative UDP-N-acetyl-D-galactosamine dehydrogenase was identified and cloned from Vibrio vulnificus. LPS production was altered by disruption of the wbpO gene through allelic exchanges. The function of the wbpO gene in virulence assessed in vitro and in mice revealed that WbpO is important in both the pathogenesis of V. vulnificus and the biosynthesis of LPS.

Original languageEnglish
Pages (from-to)808-816
Number of pages9
JournalJournal of Microbiology and Biotechnology
Volume16
Issue number5
Publication statusPublished - 2006 May 1

Fingerprint

Vibrio vulnificus
Essential Genes
Lipopolysaccharides
Galactosamine
Genes
Acetylgalactosamine
Gene encoding
Uridine Diphosphate
Biosynthesis
Oxidoreductases
Virulence

Keywords

  • LPS
  • Pathogenesis
  • V. vulnificus wbpO

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

Cite this

Identification and characterization of the wbpO gene essential for lipopolysaccharide synthesis in Vibrio vulnificus. / Park, Na Young; Lee, Jeong Hyun; Lee, Byung Cheol; Kim, Tae Sung; Choi, Sang Ho.

In: Journal of Microbiology and Biotechnology, Vol. 16, No. 5, 01.05.2006, p. 808-816.

Research output: Contribution to journalArticle

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