Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma

Soo Mee Bang, Young Ree Kim, Han Ik Cho, Hyun Sook Chi, Eul Ju Seo, Chan Jeoung Park, Soo Jin Yoo, Hee Chan Kim, Honggu Chun, Hyun Chung Min, Bo Ra Oh, Tae Young Kim, Jae Hoon Lee, Dong Soon Lee

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Abstract

The most frequent genetic aberrations in multiple myeloma (MM) are 13q deletions and translocations involving the immunoglobulin heavy chain gene (IGH). There have been no reports on the cytogenetic abnormalities found in Korean patients with MM. We investigated the actual prevalence and prognostic value of cytogenetic changes using fluorescence in situ hybridization (FISH). FISH studies with 12 different specific probes for the regions containing the genes or chromosome regions (13q, 1q, IGH, p53, MLL, p16, CEP 7, CEP 11, and CEP 12) were performed in 128 patients. The most frequent change found was 13q deletion (48%), followed by trisomy 1q (45%), IGH translocation (37%), and trisomy 11 (26%). Among the three different probes used to detect 13q deletion, D13S25 (48/58) was the most sensitive probe compared to RB (43/58) and D13S319 (39/58). Among the patients showing one or more changes by FISH, 75% (82/110) had a 13q deletion, a trisomy 1q, or an IGH translocation. Azotemia, anemia, thrombocytopenia, intramedullary plasmacytosis, and stage were significantly associated with the 13q deletion; serum β2-microglobulin, thrombocytopenia, and intramedullary plasmacytosis were also related to trisomy 1q. The pattern of molecular cytogenetic changes in Korean patients with MM is somewhat different from what has been observed in reported Caucasian populations: 37 versus 50-70% with regard to the IGH translocation. The prevalence of the 13q deletion was similar in Korean and Caucasian populations, 48 versus 30-50%. We suggest that the detection of at least these three genetic changes, 13q- trisomy 1q, and an IGH rearrangement, would be helpful for follow-up of Korean patients with MM.

Original languageEnglish
Pages (from-to)124-132
Number of pages9
JournalCancer Genetics and Cytogenetics
Volume168
Issue number2
DOIs
Publication statusPublished - 2006 Jul 15
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Bang, S. M., Kim, Y. R., Cho, H. I., Chi, H. S., Seo, E. J., Park, C. J., Yoo, S. J., Kim, H. C., Chun, H., Min, H. C., Oh, B. R., Kim, T. Y., Lee, J. H., & Lee, D. S. (2006). Identification of 13q deletion, trisomy 1q, and IgH rearrangement as the most frequent chromosomal changes found in Korean patients with multiple myeloma. Cancer Genetics and Cytogenetics, 168(2), 124-132. https://doi.org/10.1016/j.cancergencyto.2006.02.015