Identification of 15 loci influencing height in a Korean population

Jae Jung Kim; Hae In Lee; Taesung Park; Kyunga Kim; Jong Eun Lee; Nam Han Cho; Chol Shin; Yoon Shin Cho; Jong Young Lee; Bok Ghee Han; Han Wook Yoo; Jong Keuk Lee

doi:10.1038/jhg.2009.116

Identification of 15 loci influencing height in a Korean population

Jae Jung Kim, Hae In Lee, Taesung Park, Kyunga Kim, Jong Eun Lee, Nam Han Cho, Chol Shin, Yoon Shin Cho, Jong Young Lee, Bok Ghee Han, Han Wook Yoo, Jong Keuk Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

Height is a complex genetic trait that involves multiple genetic loci. Recently, 44 loci associated with height were identified in Caucasian individuals by large-scale genome-wide association (GWA) studies. To identify genetic variants influencing height in the Korean population, we analyzed GWA data from 8842 Korean individuals and identified 15 genomic regions with one or more sequence variants associated with height (P<1 × 10^-5). Of these, eight loci were newly identified in Koreans (SUPT3H, EXT1, FREM1, PALM2-AKAP2, NUP37-PMCH, IGF1, KRT20 and ANKRD60). The 15 significant loci account for approximately 1.0% of height variation, with a 3.7-cm difference between individuals with ≤8 height-increasing alleles (5.1%) and ≥19 height-increasing alleles (4.2%). We also examined the associations between height loci and idiopathic short stature (ISS). Five loci (SPAG17, KBTBD8, HHIP, HIST1H1D and ACAN) were significantly associated with ISS (uncorrected P<0.05), indicating that height-associated genes in the adult population are involved in extreme cases of short stature in children. This study validates previous reports of loci associated with human height and identified novel candidate regions involved in human growth and development.

Original language	English
Pages (from-to)	27-31
Number of pages	5
Journal	Journal of Human Genetics
Volume	55
Issue number	1
DOIs	https://doi.org/10.1038/jhg.2009.116
Publication status	Published - 2010 Jan

Keywords

Genome-wide association study
Height
Idiopathic short stature
Korean
Single-nucleotide polymorphism

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1038/jhg.2009.116

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Identification of 15 loci influencing height in a Korean population. / Kim, Jae Jung; Lee, Hae In; Park, Taesung; Kim, Kyunga; Lee, Jong Eun; Cho, Nam Han; Shin, Chol; Cho, Yoon Shin; Lee, Jong Young; Han, Bok Ghee; Yoo, Han Wook; Lee, Jong Keuk.

In: Journal of Human Genetics, Vol. 55, No. 1, 01.2010, p. 27-31.

Research output: Contribution to journal › Article › peer-review

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abstract = "Height is a complex genetic trait that involves multiple genetic loci. Recently, 44 loci associated with height were identified in Caucasian individuals by large-scale genome-wide association (GWA) studies. To identify genetic variants influencing height in the Korean population, we analyzed GWA data from 8842 Korean individuals and identified 15 genomic regions with one or more sequence variants associated with height (P<1 × 10-5). Of these, eight loci were newly identified in Koreans (SUPT3H, EXT1, FREM1, PALM2-AKAP2, NUP37-PMCH, IGF1, KRT20 and ANKRD60). The 15 significant loci account for approximately 1.0% of height variation, with a 3.7-cm difference between individuals with ≤8 height-increasing alleles (5.1%) and ≥19 height-increasing alleles (4.2%). We also examined the associations between height loci and idiopathic short stature (ISS). Five loci (SPAG17, KBTBD8, HHIP, HIST1H1D and ACAN) were significantly associated with ISS (uncorrected P<0.05), indicating that height-associated genes in the adult population are involved in extreme cases of short stature in children. This study validates previous reports of loci associated with human height and identified novel candidate regions involved in human growth and development.",

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Identification of 15 loci influencing height in a Korean population

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