Identification of a novel insect neuropeptide, CNMa and its receptor

Sung Hwan Jung, Jae Hyuk Lee, Hyo Seok Chae, Jae Young Seong, Yoonseong Park, Zee Yong Park, Young Joon Kim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

To identify ligands for orphan GPCRs, we searched novel neuropeptide genes in the Drosophila melanogaster genome. Here, we describe CNMa, a novel cyclic neuropeptide that is a highly potent and selective agonist for the orphan GPCR, CG33696 (CNMaR). Phylogenetic analysis revealed that arthropod species have two paralogous CNMaRs, but many taxa retain only one. Drosophila CNMa potently activates CNMaR-2 from Apis mellifera, suggesting both receptors are functional. Although CNMa is conserved in most arthropods, Lepidoptera lack the CNMa gene. However, they retain the CNMaR gene. Bombyx CNMaR showed low sensitivity to Drosophila CNMa, hinting toward the existence of additional CNMaR ligand(s).

Original languageEnglish
Pages (from-to)2037-2041
Number of pages5
JournalFEBS Letters
Volume588
Issue number12
DOIs
Publication statusPublished - 2014 Jul 5

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Neuropeptides
Insects
Arthropods
Genes
Drosophila
Ligands
Lepidoptera
Bombyx
Bees
Drosophila melanogaster
Genome

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Jung, S. H., Lee, J. H., Chae, H. S., Seong, J. Y., Park, Y., Park, Z. Y., & Kim, Y. J. (2014). Identification of a novel insect neuropeptide, CNMa and its receptor. FEBS Letters, 588(12), 2037-2041. https://doi.org/10.1016/j.febslet.2014.04.028

Identification of a novel insect neuropeptide, CNMa and its receptor. / Jung, Sung Hwan; Lee, Jae Hyuk; Chae, Hyo Seok; Seong, Jae Young; Park, Yoonseong; Park, Zee Yong; Kim, Young Joon.

In: FEBS Letters, Vol. 588, No. 12, 05.07.2014, p. 2037-2041.

Research output: Contribution to journalArticle

Jung, SH, Lee, JH, Chae, HS, Seong, JY, Park, Y, Park, ZY & Kim, YJ 2014, 'Identification of a novel insect neuropeptide, CNMa and its receptor', FEBS Letters, vol. 588, no. 12, pp. 2037-2041. https://doi.org/10.1016/j.febslet.2014.04.028
Jung, Sung Hwan ; Lee, Jae Hyuk ; Chae, Hyo Seok ; Seong, Jae Young ; Park, Yoonseong ; Park, Zee Yong ; Kim, Young Joon. / Identification of a novel insect neuropeptide, CNMa and its receptor. In: FEBS Letters. 2014 ; Vol. 588, No. 12. pp. 2037-2041.
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