Identification of a peptidergic pathway critical to satiety responses in drosophila

Soohong Min, Hyo Seok Chae, Yong Hoon Jang, Sekyu Choi, Sion Lee, Yong Taek Jeong, Walton D. Jones, Seok Jun Moon, Young Joon Kim, Jongkyeong Chung

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Although several neural pathways have been implicated in feeding behaviors in mammals [1-7], it remains unclear how the brain coordinates feeding motivations to maintain a constant body weight (BW). Here, we identified a neuropeptide pathway important for the satiety and BW control in Drosophila. Silencing of myoinhibitory peptide (MIP) neurons significantly increased BW through augmented food intake and fat storage. Likewise, the loss-of-function mutation of mip also increased feeding and BW. Suppressing the MIP pathway induced satiated flies to behave like starved ones, with elevated sensitivity toward food. Conversely, activating MIP neurons greatly decreased food intake and BW and markedly blunted the sensitivity of starved flies toward food. Upon terminating the activation protocol of MIP neurons, the decreased BW reverts rapidly to the normal level through a strong feeding rebound, indicating the switch-like role of MIP pathway in feeding. Surprisingly, the MIP-mediated BW decrease occurred independently of sex peptide receptor (SPR), the only known receptor for MIP, suggesting the presence of a yet-unknown MIP receptor. Together, our results reveal a novel anorexigenic pathway that controls satiety in Drosophila and provide a new avenue to study how the brain actively maintains a constant BW.

Original languageEnglish
Pages (from-to)814-820
Number of pages7
JournalCurrent Biology
Volume26
Issue number6
DOIs
Publication statusPublished - 2016 Mar 21
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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