Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI

Guoshi Li, Yujie Liu, Yanting Zheng, Ye Wu, Pew Thian Yap, Shijun Qiu, Han Zhang, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Resting-state functional magnetic resonance imaging (rs-fMRI) studies have focused primarily on characterizing functional or effective connectivity of discrete brain regions. A major drawback of this approach is that it does not provide a mechanistic understanding of brain cognitive function or dysfunction at cellular and circuit levels. To overcome this limitation, we combined the methods of computational neuroscience with traditional macroscale connectomic analysis and developed a Multiscale Neural Model Inversion (MNMI) framework that links microscale circuit interaction with macroscale network dynamics and estimates both local coupling and inter-regional connections via stochastic optimization based on blood oxygen-level dependent (BOLD) rs-fMRI. We applied this method to the rs-fMRI data of 66 normal healthy subjects and 66 individuals with major depressive disorder (MDD) to identify potential biomarkers at both local circuit and global network level. Results suggest that the recurrent excitation and inhibition within the dorsal lateral prefrontal cortex (dlPFC) might be disrupted in MDD, consistent with the commonly accepted hypothetical model of MDD. In addition, recurrent excitation in the thalamus was found to be abnormally elevated, which may be responsible to abnormal thalamocortical oscillations often observed in MDD. Overall, our modeling approach holds the promise to overcome the limitation of traditional large-scale connectome modeling by providing hidden mechanistic insights into neuroanatomy, circuit dynamics and pathophysiology.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings
EditorsDinggang Shen, Pew-Thian Yap, Tianming Liu, Terry M. Peters, Ali Khan, Lawrence H. Staib, Caroline Essert, Sean Zhou
PublisherSpringer
Pages682-690
Number of pages9
ISBN (Print)9783030322472
DOIs
Publication statusPublished - 2019 Jan 1
Externally publishedYes
Event22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019 - Shenzhen, China
Duration: 2019 Oct 132019 Oct 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11766 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019
CountryChina
CityShenzhen
Period19/10/1319/10/17

Fingerprint

Functional Magnetic Resonance Imaging
Disorder
Networks (circuits)
Modeling
Brain
Excitation
Computational Neuroscience
Pathophysiology
Network Dynamics
Stochastic Optimization
Biomarkers
Cortex
Blood
Oxygen
Lateral
Inversion
Connectivity
Oscillation
Magnetic Resonance Imaging
Dependent

Keywords

  • Functional connectivity
  • Major depressive disorder
  • Neural mass model
  • Resting-state fMRI
  • Stochastic optimization

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Li, G., Liu, Y., Zheng, Y., Wu, Y., Yap, P. T., Qiu, S., ... Shen, D. (2019). Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI. In D. Shen, P-T. Yap, T. Liu, T. M. Peters, A. Khan, L. H. Staib, C. Essert, ... S. Zhou (Eds.), Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings (pp. 682-690). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11766 LNCS). Springer. https://doi.org/10.1007/978-3-030-32248-9_76

Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI. / Li, Guoshi; Liu, Yujie; Zheng, Yanting; Wu, Ye; Yap, Pew Thian; Qiu, Shijun; Zhang, Han; Shen, Dinggang.

Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings. ed. / Dinggang Shen; Pew-Thian Yap; Tianming Liu; Terry M. Peters; Ali Khan; Lawrence H. Staib; Caroline Essert; Sean Zhou. Springer, 2019. p. 682-690 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11766 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, G, Liu, Y, Zheng, Y, Wu, Y, Yap, PT, Qiu, S, Zhang, H & Shen, D 2019, Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI. in D Shen, P-T Yap, T Liu, TM Peters, A Khan, LH Staib, C Essert & S Zhou (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11766 LNCS, Springer, pp. 682-690, 22nd International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2019, Shenzhen, China, 19/10/13. https://doi.org/10.1007/978-3-030-32248-9_76
Li G, Liu Y, Zheng Y, Wu Y, Yap PT, Qiu S et al. Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI. In Shen D, Yap P-T, Liu T, Peters TM, Khan A, Staib LH, Essert C, Zhou S, editors, Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings. Springer. 2019. p. 682-690. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-030-32248-9_76
Li, Guoshi ; Liu, Yujie ; Zheng, Yanting ; Wu, Ye ; Yap, Pew Thian ; Qiu, Shijun ; Zhang, Han ; Shen, Dinggang. / Identification of Abnormal Circuit Dynamics in Major Depressive Disorder via Multiscale Neural Modeling of Resting-State fMRI. Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 - 22nd International Conference, Proceedings. editor / Dinggang Shen ; Pew-Thian Yap ; Tianming Liu ; Terry M. Peters ; Ali Khan ; Lawrence H. Staib ; Caroline Essert ; Sean Zhou. Springer, 2019. pp. 682-690 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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